Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction

Yating Zhao; Binbin Huang; Chao Yang; Wujiong Xia

doi:10.1021/acs.orglett.6b01371

Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction

Yating Zhao
, Binbin Huang
, Chao Yang
, Wujiong Xia^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering, Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

A transition-metal-free approach was disclosed for intermolecular aryl C-N bonds formation between phenols and cyclic anilines via cross-dehydrogenative coupling (CDC) amination that was mediated by visible light, wherein K₂S₂O₈ served as an external oxidant. The salient features of this protocol include circumventing the requirement for prefunctionalized starting materials and achieving single regioselectivity of amination adducts at room temperature.

Original language	English
Pages (from-to)	3326-3329
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	14
DOIs	https://doi.org/10.1021/acs.orglett.6b01371
State	Published - 15 Jul 2016
Externally published	Yes

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title = "Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction",

abstract = "A transition-metal-free approach was disclosed for intermolecular aryl C-N bonds formation between phenols and cyclic anilines via cross-dehydrogenative coupling (CDC) amination that was mediated by visible light, wherein K2S2O8 served as an external oxidant. The salient features of this protocol include circumventing the requirement for prefunctionalized starting materials and achieving single regioselectivity of amination adducts at room temperature.",

author = "Yating Zhao and Binbin Huang and Chao Yang and Wujiong Xia",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = jul,

day = "15",

doi = "10.1021/acs.orglett.6b01371",

language = "英语",

volume = "18",

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journal = "Organic Letters",

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T1 - Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction

AU - Zhao, Yating

AU - Huang, Binbin

AU - Yang, Chao

AU - Xia, Wujiong

PY - 2016/7/15

Y1 - 2016/7/15

N2 - A transition-metal-free approach was disclosed for intermolecular aryl C-N bonds formation between phenols and cyclic anilines via cross-dehydrogenative coupling (CDC) amination that was mediated by visible light, wherein K2S2O8 served as an external oxidant. The salient features of this protocol include circumventing the requirement for prefunctionalized starting materials and achieving single regioselectivity of amination adducts at room temperature.

AB - A transition-metal-free approach was disclosed for intermolecular aryl C-N bonds formation between phenols and cyclic anilines via cross-dehydrogenative coupling (CDC) amination that was mediated by visible light, wherein K2S2O8 served as an external oxidant. The salient features of this protocol include circumventing the requirement for prefunctionalized starting materials and achieving single regioselectivity of amination adducts at room temperature.

UR - https://www.scopus.com/pages/publications/84978687305

U2 - 10.1021/acs.orglett.6b01371

DO - 10.1021/acs.orglett.6b01371

M3 - 文章

AN - SCOPUS:84978687305

SN - 1523-7060

VL - 18

SP - 3326

EP - 3329

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -

Visible-Light-Promoted Direct Amination of Phenols via Oxidative Cross-Dehydrogenative Coupling Reaction

Abstract

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