Visible-Light-Promoted C2 Trifluoromethylation of Quinoline N -Oxides

Ce Liang; Wang Tao Zhuo; Yan Ning Niu; Guo Lin Gao

doi:10.1055/s-0039-1690726

Visible-Light-Promoted C2 Trifluoromethylation of Quinoline N -Oxides

Ce Liang
, Wang Tao Zhuo
, Yan Ning Niu
, Guo Lin Gao^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Nanjing Forestry University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A photoredox catalytic strategy has been described for the direct C2 trifluoromethylation of quinoline N -oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2 trifluoromethyl quinoline N -oxides at room temperature. Mechanistic studies indicated that the reaction proceeds via a radical pathway.

Original language	English
Pages (from-to)	219-226
Number of pages	8
Journal	Synthesis (Germany)
Volume	52
Issue number	2
DOIs	https://doi.org/10.1055/s-0039-1690726
State	Published - 16 Dec 2019
Externally published	Yes

Keywords

C-H functionlization
N -oxide compounds
photoredox
radicals
trifluoromethylation

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10.1055/s-0039-1690726

Cite this

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title = "Visible-Light-Promoted C2 Trifluoromethylation of Quinoline N -Oxides",

abstract = "A photoredox catalytic strategy has been described for the direct C2 trifluoromethylation of quinoline N -oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2 trifluoromethyl quinoline N -oxides at room temperature. Mechanistic studies indicated that the reaction proceeds via a radical pathway.",

keywords = "C-H functionlization, N -oxide compounds, photoredox, radicals, trifluoromethylation",

author = "Ce Liang and Zhuo, \{Wang Tao\} and Niu, \{Yan Ning\} and Gao, \{Guo Lin\}",

year = "2019",

month = dec,

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doi = "10.1055/s-0039-1690726",

language = "英语",

volume = "52",

pages = "219--226",

journal = "Synthesis (Germany)",

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TY - JOUR

T1 - Visible-Light-Promoted C2 Trifluoromethylation of Quinoline N -Oxides

AU - Liang, Ce

AU - Zhuo, Wang Tao

AU - Niu, Yan Ning

AU - Gao, Guo Lin

PY - 2019/12/16

Y1 - 2019/12/16

N2 - A photoredox catalytic strategy has been described for the direct C2 trifluoromethylation of quinoline N -oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2 trifluoromethyl quinoline N -oxides at room temperature. Mechanistic studies indicated that the reaction proceeds via a radical pathway.

AB - A photoredox catalytic strategy has been described for the direct C2 trifluoromethylation of quinoline N -oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2 trifluoromethyl quinoline N -oxides at room temperature. Mechanistic studies indicated that the reaction proceeds via a radical pathway.

KW - C-H functionlization

KW - N -oxide compounds

KW - photoredox

KW - radicals

KW - trifluoromethylation

UR - https://www.scopus.com/pages/publications/85076813635

U2 - 10.1055/s-0039-1690726

DO - 10.1055/s-0039-1690726

M3 - 文章

AN - SCOPUS:85076813635

SN - 0039-7881

VL - 52

SP - 219

EP - 226

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 2

ER -

Visible-Light-Promoted C2 Trifluoromethylation of Quinoline N -Oxides

Abstract

Keywords

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