Skip to main navigation Skip to search Skip to main content

Using maximum entropy model to extract protein-protein interaction information from biomedical literature

  • School of Computer Science and Technology, Harbin Institute of Technology

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Protein-Protein interaction (PPI) information play a vital role in biological research. This work proposes a two-step machine learning based method to extract PPI information from biomedical literature. Both steps use Maximum Entropy (ME) model. The first step is designed to estimate whether a sentence in a literature contains PPI information. The second step is to judge whether each protein pair in a sentence has interaction. Two steps are combined through adding the outputs of the first step to the model of the second step as features. Experiments show the method achieves a total accuracy of 81.9% in BC-PPI corpus and the outputs of the first step can effectively prompt the performance of the PPI information extraction.

Original languageEnglish
Title of host publicationAdvanced Intelligent Computing Theories and Applications
Subtitle of host publicationWith Aspects of Theoretical and Methodological Issues - Third International Conference on Intelligent Computing, ICIC 2007, Proceedings
PublisherSpringer Verlag
Pages730-737
Number of pages8
ISBN (Print)9783540741701
DOIs
StatePublished - 2007
Externally publishedYes
Event3rd International Conference on Intelligent Computing, ICIC 2007 - Qingdao, China
Duration: 21 Aug 200724 Aug 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4681 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference3rd International Conference on Intelligent Computing, ICIC 2007
Country/TerritoryChina
CityQingdao
Period21/08/0724/08/07

Keywords

  • Machine learning
  • Maximum entropy
  • Protein-protein interaction
  • Text mining

Fingerprint

Dive into the research topics of 'Using maximum entropy model to extract protein-protein interaction information from biomedical literature'. Together they form a unique fingerprint.

Cite this