The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt-DNA adducts

Yafeng He; Jian Yuan; Yuchen Qiao; Dan Wang; Weizhong Chen; Xichun Liu; Hao Chen; Zijian Guo

doi:10.1039/c5cc05257b

The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt-DNA adducts

Yafeng He
, Jian Yuan
, Yuchen Qiao
, Dan Wang
, Weizhong Chen
, Xichun Liu
, Hao Chen^*
, Zijian Guo

^*Corresponding author for this work

Nanjing University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In order to systematically investigate the influence of carrier ligands on the interaction of Pt-DNA adducts with damage recognition proteins, a series of DNA probes containing 1,2-GG platinum compound crosslinks using cisplatin, oxaliplatin, (S,S-DACH)PtCl₂ and (cis-1,4-DACH)PtCl₂ (kiteplatin) has been constructed. These complexes share similar DNA binding properties although they exhibit quite different cytotoxicity. It is revealed that HMGB1 (high-mobility group protein B1) was the most commonly found protein that recognizes all Pt(ii)-DNA probes and prefers cisplatin-DNA probes more than the others. Interestingly, an important component of the replication protein A complex, RPA2, was found to bind to kiteplatin much more tightly than other proteins. These results may be important for the interpretation of the roles of carrier ligands in platinum(ii)-based anticancer complexes.

Original language	English
Pages (from-to)	14064-14067
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	74
DOIs	https://doi.org/10.1039/c5cc05257b
State	Published - 28 Jul 2015
Externally published	Yes

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title = "The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt-DNA adducts",

abstract = "In order to systematically investigate the influence of carrier ligands on the interaction of Pt-DNA adducts with damage recognition proteins, a series of DNA probes containing 1,2-GG platinum compound crosslinks using cisplatin, oxaliplatin, (S,S-DACH)PtCl2 and (cis-1,4-DACH)PtCl2 (kiteplatin) has been constructed. These complexes share similar DNA binding properties although they exhibit quite different cytotoxicity. It is revealed that HMGB1 (high-mobility group protein B1) was the most commonly found protein that recognizes all Pt(ii)-DNA probes and prefers cisplatin-DNA probes more than the others. Interestingly, an important component of the replication protein A complex, RPA2, was found to bind to kiteplatin much more tightly than other proteins. These results may be important for the interpretation of the roles of carrier ligands in platinum(ii)-based anticancer complexes.",

author = "Yafeng He and Jian Yuan and Yuchen Qiao and Dan Wang and Weizhong Chen and Xichun Liu and Hao Chen and Zijian Guo",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2015",

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doi = "10.1039/c5cc05257b",

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T1 - The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt-DNA adducts

AU - He, Yafeng

AU - Yuan, Jian

AU - Qiao, Yuchen

AU - Wang, Dan

AU - Chen, Weizhong

AU - Liu, Xichun

AU - Chen, Hao

AU - Guo, Zijian

PY - 2015/7/28

Y1 - 2015/7/28

N2 - In order to systematically investigate the influence of carrier ligands on the interaction of Pt-DNA adducts with damage recognition proteins, a series of DNA probes containing 1,2-GG platinum compound crosslinks using cisplatin, oxaliplatin, (S,S-DACH)PtCl2 and (cis-1,4-DACH)PtCl2 (kiteplatin) has been constructed. These complexes share similar DNA binding properties although they exhibit quite different cytotoxicity. It is revealed that HMGB1 (high-mobility group protein B1) was the most commonly found protein that recognizes all Pt(ii)-DNA probes and prefers cisplatin-DNA probes more than the others. Interestingly, an important component of the replication protein A complex, RPA2, was found to bind to kiteplatin much more tightly than other proteins. These results may be important for the interpretation of the roles of carrier ligands in platinum(ii)-based anticancer complexes.

AB - In order to systematically investigate the influence of carrier ligands on the interaction of Pt-DNA adducts with damage recognition proteins, a series of DNA probes containing 1,2-GG platinum compound crosslinks using cisplatin, oxaliplatin, (S,S-DACH)PtCl2 and (cis-1,4-DACH)PtCl2 (kiteplatin) has been constructed. These complexes share similar DNA binding properties although they exhibit quite different cytotoxicity. It is revealed that HMGB1 (high-mobility group protein B1) was the most commonly found protein that recognizes all Pt(ii)-DNA probes and prefers cisplatin-DNA probes more than the others. Interestingly, an important component of the replication protein A complex, RPA2, was found to bind to kiteplatin much more tightly than other proteins. These results may be important for the interpretation of the roles of carrier ligands in platinum(ii)-based anticancer complexes.

UR - https://www.scopus.com/pages/publications/84940850714

U2 - 10.1039/c5cc05257b

DO - 10.1039/c5cc05257b

M3 - 文章

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AN - SCOPUS:84940850714

SN - 1359-7345

VL - 51

SP - 14064

EP - 14067

JO - Chemical Communications

JF - Chemical Communications

IS - 74

ER -

The role of carrier ligands of platinum(ii) anticancer complexes in the protein recognition of Pt-DNA adducts

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