The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

Nelson O. Gekara; Hui Jiang

doi:10.1126/scisignal.aax3521

The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

Nelson O. Gekara^*
, Hui Jiang

^*Corresponding author for this work

Stockholm University
Umeå University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.

Original language	English
Article number	eaax3521
Journal	Science Signaling
Volume	12
Issue number	581
DOIs	https://doi.org/10.1126/scisignal.aax3521
State	Published - 14 May 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/scisignal.aax3521

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title = "The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?",

abstract = "Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.",

author = "Gekara, \{Nelson O.\} and Hui Jiang",

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AU - Jiang, Hui

PY - 2019/5/14

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N2 - Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.

AB - Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.

UR - https://www.scopus.com/pages/publications/85066266617

U2 - 10.1126/scisignal.aax3521

DO - 10.1126/scisignal.aax3521

M3 - 文章

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AN - SCOPUS:85066266617

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JO - Science Signaling

JF - Science Signaling

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ER -

The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

Abstract

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