Targeted Delivery of 5-Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy

Xing Ma; Qiuyu Qu; Yanli Zhao

doi:10.1021/acsami.5b03087

Targeted Delivery of 5-Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy

Xing Ma
, Qiuyu Qu
, Yanli Zhao^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro. (Figure Presented).

Original language	English
Pages (from-to)	10671-10676
Number of pages	6
Journal	ACS Applied Materials and Interfaces
Volume	7
Issue number	20
DOIs	https://doi.org/10.1021/acsami.5b03087
State	Published - 27 May 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aminolevulinic acid
Hollow mesoporous silica nanoparticles
Photodynamic therapy
Skin cancer
Targeted delivery

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10.1021/acsami.5b03087

Cite this

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title = "Targeted Delivery of 5-Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy",

abstract = "5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro. (Figure Presented).",

keywords = "Aminolevulinic acid, Hollow mesoporous silica nanoparticles, Photodynamic therapy, Skin cancer, Targeted delivery",

author = "Xing Ma and Qiuyu Qu and Yanli Zhao",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = may,

day = "27",

doi = "10.1021/acsami.5b03087",

language = "英语",

volume = "7",

pages = "10671--10676",

journal = "ACS Applied Materials and Interfaces",

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publisher = "American Chemical Society",

number = "20",

}

TY - JOUR

T1 - Targeted Delivery of 5-Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy

AU - Ma, Xing

AU - Qu, Qiuyu

AU - Zhao, Yanli

PY - 2015/5/27

Y1 - 2015/5/27

N2 - 5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro. (Figure Presented).

AB - 5-Aminolevulinic acid (5-ALA) is a precursor of a strong photosensitizer, protoporphyrin IX (PphIX), for photodynamic therapy (PDT). Developing appropriate delivery carriers that can assist 5-ALA in bypassing the lipophilic barrier to directly enter into cancer cells is a research focus. The improved delivery of 5-ALA is even important for skin cancer therapy through PDT process. In this work, targeting ligand folic acid (FA)-functionalized hollow mesoporous silica nanoparticles (HMSNPs) were fabricated to deliver 5-ALA for PDT against B16F10 skin cancer cells. The FA targeting ligand enabled selective endocytosis of 5-ALA loaded HMSNPs into cancer cells. PphIX formed from delivered 5-ALA exhibited high photocytotoxicity to the cancer cells in vitro. (Figure Presented).

KW - Aminolevulinic acid

KW - Hollow mesoporous silica nanoparticles

KW - Photodynamic therapy

KW - Skin cancer

KW - Targeted delivery

UR - https://www.scopus.com/pages/publications/84930642560

U2 - 10.1021/acsami.5b03087

DO - 10.1021/acsami.5b03087

M3 - 文章

C2 - 25974979

AN - SCOPUS:84930642560

SN - 1944-8244

VL - 7

SP - 10671

EP - 10676

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 20

ER -

Targeted Delivery of 5-Aminolevulinic Acid by Multifunctional Hollow Mesoporous Silica Nanoparticles for Photodynamic Skin Cancer Therapy

Abstract

UN SDGs

Keywords

Access to Document

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