Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization

Xin Huang; Nicole Hauptmann; Dietmar Appelhans; Petr Formanek; Simon Frank; Stefan Kaskel; Achim Temme; Brigitte Voit

doi:10.1002/smll.201201397

Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization

Xin Huang
, Nicole Hauptmann
, Dietmar Appelhans
, Petr Formanek
, Simon Frank
, Stefan Kaskel
, Achim Temme
, Brigitte Voit^*

^*Corresponding author for this work

Leibniz Institute of Polymer Research Dresden
Technische Universität Dresden

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

Original language	English
Pages (from-to)	3579-3583
Number of pages	5
Journal	Small
Volume	8
Issue number	23
DOIs	https://doi.org/10.1002/smll.201201397
State	Published - 7 Dec 2012
Externally published	Yes

Keywords

ATRP
RAFT
bi-functionalization
mesoporous silica nanoparticles
nanocarriers

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10.1002/smll.201201397

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title = "Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization",

abstract = "Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.",

keywords = "ATRP, RAFT, bi-functionalization, mesoporous silica nanoparticles, nanocarriers",

author = "Xin Huang and Nicole Hauptmann and Dietmar Appelhans and Petr Formanek and Simon Frank and Stefan Kaskel and Achim Temme and Brigitte Voit",

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T1 - Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization

AU - Huang, Xin

AU - Hauptmann, Nicole

AU - Appelhans, Dietmar

AU - Formanek, Petr

AU - Frank, Simon

AU - Kaskel, Stefan

AU - Temme, Achim

AU - Voit, Brigitte

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

AB - Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

KW - ATRP

KW - RAFT

KW - bi-functionalization

KW - mesoporous silica nanoparticles

KW - nanocarriers

UR - https://www.scopus.com/pages/publications/84870417494

U2 - 10.1002/smll.201201397

DO - 10.1002/smll.201201397

M3 - 文章

C2 - 22911545

AN - SCOPUS:84870417494

SN - 1613-6810

VL - 8

SP - 3579

EP - 3583

JO - Small

JF - Small

IS - 23

ER -

Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization

Abstract

Keywords

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