Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

V. L. Gein; M. I. Kazantseva; L. I. Varkentin; T. M. Zamaraeva; A. N. Yankin; E. V. Beletskii; V. V. Novikova

doi:10.1134/S1070363220080083

Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

V. L. Gein^*
, M. I. Kazantseva
, L. I. Varkentin
, T. M. Zamaraeva
, A. N. Yankin
, E. V. Beletskii
, V. V. Novikova

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Abstract: The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.

Original language	English
Pages (from-to)	1426-1431
Number of pages	6
Journal	Russian Journal of General Chemistry
Volume	90
Issue number	8
DOIs	https://doi.org/10.1134/S1070363220080083
State	Published - 1 Aug 2020
Externally published	Yes

Keywords

N,N-dimethyltryptamine heterocyclic analogues
antimicrobial activity
pyrrolidine-2,3-dione derivatives

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10.1134/S1070363220080083

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@article{d0260df32d5b41dfbb2a74c636742e54,

title = "Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones",

abstract = "Abstract: The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.",

keywords = "N,N-dimethyltryptamine heterocyclic analogues, antimicrobial activity, pyrrolidine-2,3-dione derivatives",

author = "Gein, \{V. L.\} and Kazantseva, \{M. I.\} and Varkentin, \{L. I.\} and Zamaraeva, \{T. M.\} and Yankin, \{A. N.\} and Beletskii, \{E. V.\} and Novikova, \{V. V.\}",

note = "Publisher Copyright: {\textcopyright} 2020, Pleiades Publishing, Ltd.",

year = "2020",

month = aug,

day = "1",

doi = "10.1134/S1070363220080083",

language = "英语",

volume = "90",

pages = "1426--1431",

journal = "Russian Journal of General Chemistry",

issn = "1070-3632",

publisher = "Pleiades Publishing",

number = "8",

}

TY - JOUR

T1 - Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

AU - Gein, V. L.

AU - Kazantseva, M. I.

AU - Varkentin, L. I.

AU - Zamaraeva, T. M.

AU - Yankin, A. N.

AU - Beletskii, E. V.

AU - Novikova, V. V.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Abstract: The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.

AB - Abstract: The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.

KW - N,N-dimethyltryptamine heterocyclic analogues

KW - antimicrobial activity

KW - pyrrolidine-2,3-dione derivatives

UR - https://www.scopus.com/pages/publications/85091038289

U2 - 10.1134/S1070363220080083

DO - 10.1134/S1070363220080083

M3 - 文章

AN - SCOPUS:85091038289

SN - 1070-3632

VL - 90

SP - 1426

EP - 1431

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

IS - 8

ER -

Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

Abstract

Keywords

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