Surface characteristics and biological properties of paclitaxel-emdedding PLGA-coated TiNi alloy

Surface characteristics and biological properties of paclitaxel-emdedding PLGA-coated TiNi alloy has been studied systematically. Surface topography, chemical composition, paclitaxel cumulative release rate and hemocompatibility of drug-embedding coatings were studied by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), high performance of liquid chromatography (HPLC) and platelet adhesion test, respectively. XPS results indicate that the chemical composition and microstructure of TiNi alloy after coating changes with the amount of drug; HPLC results show that paclitaxel releases from the coating was slow in pH=7.4 PBS solution at the beginning of test, and the cumulative release amount of the paclitaxel increases slowly with increasing of release time; It has been found that the amount of platelets adhered on coated TiNi containing 0%, 10%, 20%, 30% paclitaxel are greater than that of the untreated TiNi alloy. And with the increase of drug dosage, the amount of adhered platelets increase and the shape of platelets change obviously when the contents of paclitaxel reach 30%, the platelets adhered on samples exhibit a phenomena of significant accumulation.