TY - GEN
T1 - Structural changes of cingulate cortex in post stroke depression
AU - Ye, Chenfei
AU - Wu, Jun
AU - Chen, Xuhui
AU - Zhang, Changle
AU - Li, Hengtong
AU - Mao, Shuai
AU - Ma, Heather T.
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/10/13
Y1 - 2016/10/13
N2 - Disruption of neural connections among regions regulating mood and cognition rather than cerebrovascular lesions may contribute to post-stroke depression (PSD). In this paper, we hypothesized that structural abnormalities in white matter structure like cingulate cortex induced by focal infarcts would play a role in mood regulation or depression after stroke onset. Various DTI coefficients including FA, RD and ADC with multiple signal distribution measurements were collected and statistically analyzed. The results identify significant differences in volume and multiple diffusion indices of DTI intensity distribution in cingulate cortex between PSD patients and the normal control. It indicates the neuronal loss secondary to demyelination in cingulate cortex due to stroke. Additionally, the volume loss of cingulate cortex in PSD patients observed in the results may further demonstrate the reduction of glial cells in cingulate cortex, as the axonal number/size changed little.
AB - Disruption of neural connections among regions regulating mood and cognition rather than cerebrovascular lesions may contribute to post-stroke depression (PSD). In this paper, we hypothesized that structural abnormalities in white matter structure like cingulate cortex induced by focal infarcts would play a role in mood regulation or depression after stroke onset. Various DTI coefficients including FA, RD and ADC with multiple signal distribution measurements were collected and statistically analyzed. The results identify significant differences in volume and multiple diffusion indices of DTI intensity distribution in cingulate cortex between PSD patients and the normal control. It indicates the neuronal loss secondary to demyelination in cingulate cortex due to stroke. Additionally, the volume loss of cingulate cortex in PSD patients observed in the results may further demonstrate the reduction of glial cells in cingulate cortex, as the axonal number/size changed little.
UR - https://www.scopus.com/pages/publications/85009069232
U2 - 10.1109/EMBC.2016.7590895
DO - 10.1109/EMBC.2016.7590895
M3 - 会议稿件
C2 - 28268517
AN - SCOPUS:85009069232
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1099
EP - 1102
BT - 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
Y2 - 16 August 2016 through 20 August 2016
ER -