Stereotactic localization and visualization of the subthalamic nucleus

Wei Gao Shen; Hai Yang Wang; Zhi Guo Lin; Hong Shen; Xiao Guang Chen; Yi Li Fu; Wen Peng Gao

doi:10.3760/cma.j.issn.0366-6999.2009.20.008

Stereotactic localization and visualization of the subthalamic nucleus

Wei Gao Shen
, Hai Yang Wang
, Zhi Guo Lin^*
, Hong Shen
, Xiao Guang Chen
, Yi Li Fu
, Wen Peng Gao

^*Corresponding author for this work

Faculty of Life Sciences and Medicine

Harbin Medical University
Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: The subthalamic nucleus (STN) is widely recognized as one of the most important and commonly targeted nuclei in stereotactic and functional neurosurgery. The success of STN surgery depends on accuracy in target determination. Construction of a digitalized atlas of STN based on stereotactic MRI will play an instrumental role in the accuracy of anatomical localization. The aim of this study was to investigate the three-dimensional (3D) target location of STN in stereotactic space and construct a digitalized atlas of STN to accomplish the visualization of the STN on stereotactic MRI, thus providing clinical guidance on the precise anatomical localization of STN. Methods: One hundred and twenty healthy people volunteered to be scanned by 1.5 Tesla MRI scanning with 1-mm-thick slice in the standard stereotactic space between 2005 and 2006. One adult male was selected for 3D reconstruction of STN. The process of 3D reconstruction included identification, manual segmentation, extraction, conservation and reconstruction. Results: There was a significant correlation between the coordinates and age (P <0.05). The volume of left STN was significantly larger than the right STN, and there was a significant negative correlation between volume and age (P <0.05). The surface of the STN nucleus after 3D reconstruction appeared smooth, natural and realistic. The morphological feature of STN on the individual brain could be visualized directly in 3D. The 3D reconstructed STN could be rotated, zoomed and displayed at any direction in the stereotactic space. The anteroposterior diameter of the STN nucleus was longer than the vertical and transverse diameters in 3D space. The 3D reconstruction of STN manifested typical structure of the "dual lens". Conclusions: The visualization of individual brain atlas based on stereotactic MRI is feasible. However, software for automated segmentation, extraction and registration of MR images need to be further developed.

Original language	English
Pages (from-to)	2438-2443
Number of pages	6
Journal	Chinese Medical Journal
Volume	122
Issue number	20
DOIs	https://doi.org/10.3760/cma.j.issn.0366-6999.2009.20.008
State	Published - 20 Oct 2009

Keywords

Brain atlas
Stereotaxis
Subthalamic nulcleus
Visualization

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10.3760/cma.j.issn.0366-6999.2009.20.008

Cite this

@article{6720e7373f4e42b1a2fef10406224d4d,

title = "Stereotactic localization and visualization of the subthalamic nucleus",

abstract = "Background: The subthalamic nucleus (STN) is widely recognized as one of the most important and commonly targeted nuclei in stereotactic and functional neurosurgery. The success of STN surgery depends on accuracy in target determination. Construction of a digitalized atlas of STN based on stereotactic MRI will play an instrumental role in the accuracy of anatomical localization. The aim of this study was to investigate the three-dimensional (3D) target location of STN in stereotactic space and construct a digitalized atlas of STN to accomplish the visualization of the STN on stereotactic MRI, thus providing clinical guidance on the precise anatomical localization of STN. Methods: One hundred and twenty healthy people volunteered to be scanned by 1.5 Tesla MRI scanning with 1-mm-thick slice in the standard stereotactic space between 2005 and 2006. One adult male was selected for 3D reconstruction of STN. The process of 3D reconstruction included identification, manual segmentation, extraction, conservation and reconstruction. Results: There was a significant correlation between the coordinates and age (P <0.05). The volume of left STN was significantly larger than the right STN, and there was a significant negative correlation between volume and age (P <0.05). The surface of the STN nucleus after 3D reconstruction appeared smooth, natural and realistic. The morphological feature of STN on the individual brain could be visualized directly in 3D. The 3D reconstructed STN could be rotated, zoomed and displayed at any direction in the stereotactic space. The anteroposterior diameter of the STN nucleus was longer than the vertical and transverse diameters in 3D space. The 3D reconstruction of STN manifested typical structure of the {"}dual lens{"}. Conclusions: The visualization of individual brain atlas based on stereotactic MRI is feasible. However, software for automated segmentation, extraction and registration of MR images need to be further developed.",

keywords = "Brain atlas, Stereotaxis, Subthalamic nulcleus, Visualization",

author = "Shen, \{Wei Gao\} and Wang, \{Hai Yang\} and Lin, \{Zhi Guo\} and Hong Shen and Chen, \{Xiao Guang\} and Fu, \{Yi Li\} and Gao, \{Wen Peng\}",

year = "2009",

month = oct,

day = "20",

doi = "10.3760/cma.j.issn.0366-6999.2009.20.008",

language = "英语",

volume = "122",

pages = "2438--2443",

journal = "Chinese Medical Journal",

issn = "0366-6999",

publisher = "Lippincott Williams and Wilkins",

number = "20",

}

TY - JOUR

T1 - Stereotactic localization and visualization of the subthalamic nucleus

AU - Shen, Wei Gao

AU - Wang, Hai Yang

AU - Lin, Zhi Guo

AU - Shen, Hong

AU - Chen, Xiao Guang

AU - Fu, Yi Li

AU - Gao, Wen Peng

PY - 2009/10/20

Y1 - 2009/10/20

N2 - Background: The subthalamic nucleus (STN) is widely recognized as one of the most important and commonly targeted nuclei in stereotactic and functional neurosurgery. The success of STN surgery depends on accuracy in target determination. Construction of a digitalized atlas of STN based on stereotactic MRI will play an instrumental role in the accuracy of anatomical localization. The aim of this study was to investigate the three-dimensional (3D) target location of STN in stereotactic space and construct a digitalized atlas of STN to accomplish the visualization of the STN on stereotactic MRI, thus providing clinical guidance on the precise anatomical localization of STN. Methods: One hundred and twenty healthy people volunteered to be scanned by 1.5 Tesla MRI scanning with 1-mm-thick slice in the standard stereotactic space between 2005 and 2006. One adult male was selected for 3D reconstruction of STN. The process of 3D reconstruction included identification, manual segmentation, extraction, conservation and reconstruction. Results: There was a significant correlation between the coordinates and age (P <0.05). The volume of left STN was significantly larger than the right STN, and there was a significant negative correlation between volume and age (P <0.05). The surface of the STN nucleus after 3D reconstruction appeared smooth, natural and realistic. The morphological feature of STN on the individual brain could be visualized directly in 3D. The 3D reconstructed STN could be rotated, zoomed and displayed at any direction in the stereotactic space. The anteroposterior diameter of the STN nucleus was longer than the vertical and transverse diameters in 3D space. The 3D reconstruction of STN manifested typical structure of the "dual lens". Conclusions: The visualization of individual brain atlas based on stereotactic MRI is feasible. However, software for automated segmentation, extraction and registration of MR images need to be further developed.

AB - Background: The subthalamic nucleus (STN) is widely recognized as one of the most important and commonly targeted nuclei in stereotactic and functional neurosurgery. The success of STN surgery depends on accuracy in target determination. Construction of a digitalized atlas of STN based on stereotactic MRI will play an instrumental role in the accuracy of anatomical localization. The aim of this study was to investigate the three-dimensional (3D) target location of STN in stereotactic space and construct a digitalized atlas of STN to accomplish the visualization of the STN on stereotactic MRI, thus providing clinical guidance on the precise anatomical localization of STN. Methods: One hundred and twenty healthy people volunteered to be scanned by 1.5 Tesla MRI scanning with 1-mm-thick slice in the standard stereotactic space between 2005 and 2006. One adult male was selected for 3D reconstruction of STN. The process of 3D reconstruction included identification, manual segmentation, extraction, conservation and reconstruction. Results: There was a significant correlation between the coordinates and age (P <0.05). The volume of left STN was significantly larger than the right STN, and there was a significant negative correlation between volume and age (P <0.05). The surface of the STN nucleus after 3D reconstruction appeared smooth, natural and realistic. The morphological feature of STN on the individual brain could be visualized directly in 3D. The 3D reconstructed STN could be rotated, zoomed and displayed at any direction in the stereotactic space. The anteroposterior diameter of the STN nucleus was longer than the vertical and transverse diameters in 3D space. The 3D reconstruction of STN manifested typical structure of the "dual lens". Conclusions: The visualization of individual brain atlas based on stereotactic MRI is feasible. However, software for automated segmentation, extraction and registration of MR images need to be further developed.

KW - Brain atlas

KW - Stereotaxis

KW - Subthalamic nulcleus

KW - Visualization

UR - https://www.scopus.com/pages/publications/70350743301

U2 - 10.3760/cma.j.issn.0366-6999.2009.20.008

DO - 10.3760/cma.j.issn.0366-6999.2009.20.008

M3 - 文章

C2 - 20079156

AN - SCOPUS:70350743301

SN - 0366-6999

VL - 122

SP - 2438

EP - 2443

JO - Chinese Medical Journal

JF - Chinese Medical Journal

IS - 20

ER -

Stereotactic localization and visualization of the subthalamic nucleus

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Keywords

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