Solubility of clopidogrel hydrogen sulfate (Form II) in different solvents

Liangcheng Song; Minxu Li; Junbo Gong

doi:10.1021/je100022w

Solubility of clopidogrel hydrogen sulfate (Form II) in different solvents

Liangcheng Song
, Minxu Li
, Junbo Gong^*

^*Corresponding author for this work

Tianjin University

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

As an urgent need in the design and upscale of the industrial crystallization process, solubilities of clopidogrel hydrogen sulfate (Form II) in ethanol, propanol, isopropanol, butanol, and acetone were measured using a laser-monitoring technique at temperatures ranging from (278.15 to 318.15) K. The experimental data were fitted well by the modified Apelblat equation.

Original language	English
Pages (from-to)	4016-4018
Number of pages	3
Journal	Journal of Chemical and Engineering Data
Volume	55
Issue number	9
DOIs	https://doi.org/10.1021/je100022w
State	Published - 9 Sep 2010
Externally published	Yes

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title = "Solubility of clopidogrel hydrogen sulfate (Form II) in different solvents",

abstract = "As an urgent need in the design and upscale of the industrial crystallization process, solubilities of clopidogrel hydrogen sulfate (Form II) in ethanol, propanol, isopropanol, butanol, and acetone were measured using a laser-monitoring technique at temperatures ranging from (278.15 to 318.15) K. The experimental data were fitted well by the modified Apelblat equation.",

author = "Liangcheng Song and Minxu Li and Junbo Gong",

year = "2010",

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AU - Song, Liangcheng

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AU - Gong, Junbo

PY - 2010/9/9

Y1 - 2010/9/9

N2 - As an urgent need in the design and upscale of the industrial crystallization process, solubilities of clopidogrel hydrogen sulfate (Form II) in ethanol, propanol, isopropanol, butanol, and acetone were measured using a laser-monitoring technique at temperatures ranging from (278.15 to 318.15) K. The experimental data were fitted well by the modified Apelblat equation.

AB - As an urgent need in the design and upscale of the industrial crystallization process, solubilities of clopidogrel hydrogen sulfate (Form II) in ethanol, propanol, isopropanol, butanol, and acetone were measured using a laser-monitoring technique at temperatures ranging from (278.15 to 318.15) K. The experimental data were fitted well by the modified Apelblat equation.

UR - https://www.scopus.com/pages/publications/77956496721

U2 - 10.1021/je100022w

DO - 10.1021/je100022w

M3 - 文章

AN - SCOPUS:77956496721

SN - 0021-9568

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SP - 4016

EP - 4018

JO - Journal of Chemical and Engineering Data

JF - Journal of Chemical and Engineering Data

IS - 9

ER -

Solubility of clopidogrel hydrogen sulfate (Form II) in different solvents

Abstract

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