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Simulation of the formation mechanism of coronary thrombosis based on DEM-CFD coupling

  • Xu Yan Hou*
  • , Yue Tian Shi
  • , Jian Ting Yao
  • , Xin Sun
  • , Kai Liang Zhang
  • *Corresponding author for this work
  • Harbin Institute of Technology
  • Harbin Medical University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Aiming at the problem of the formation of thrombosis and coronary restenosis, the formation mechanism of thrombosis was studied in this paper. The simulation model of platelet particles was established based on the theory of discrete element. And the simulation model describing the flow of blood was built based on the principle of hemodynamic. Then by means of the DEM-CFD coupling technology, a simulation model was established to describe the circumstance that platelet flows in blood. To reveal the formation mechanism of thrombosis and solve the problem of coronary restenosis, the process of blood flowing, platelet adhering to each other and to coronary stent was simulated. The result of simulation showed that blood flow velocity has a significant influence on the formation of thrombus. The result will provide basement on the cure of thrombus and the improvement of stent in the future.

Original languageEnglish
Title of host publicationProceedings - 2015 8th International Conference on BioMedical Engineering and Informatics, BMEI 2015
EditorsLi Bai, Lipo Wang, Liangshan Shao, Jinguang Sun, Zhiyong Tao, Sen Lin
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages24-28
Number of pages5
ISBN (Electronic)9781509000227
DOIs
StatePublished - 8 Feb 2016
Event8th International Conference on BioMedical Engineering and Informatics, BMEI 2015 - Shenyang, China
Duration: 14 Oct 201516 Oct 2015

Publication series

NameProceedings - 2015 8th International Conference on BioMedical Engineering and Informatics, BMEI 2015

Conference

Conference8th International Conference on BioMedical Engineering and Informatics, BMEI 2015
Country/TerritoryChina
CityShenyang
Period14/10/1516/10/15

Keywords

  • DEM-CFD
  • formation of thrombosis
  • the aggregation and adhesion of platelet

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