TY - GEN
T1 - Simulation of effects of inward-rectifier K+ current on the automaticity of human ventricular tissue
AU - Zhang, Yue
AU - Wang, Kuanquan
AU - Zhang, Henggui
AU - Yuan, Yongfeng
N1 - Publisher Copyright:
© 2015 CCAL.
PY - 2015/2/16
Y1 - 2015/2/16
N2 - Inward-rectifier K+ current (IK1) is a major current in ventricular myocytes, which contributes both to the fourth phase of repolarization and setting the resting membrane potential. The down-regulation of IK1 could induce automaticity in human ventricular myocytes. An idealized 2D human ventricular tissue was designed in this paper, which was 100 cells in length and 400 cells in width. The effects of IK1 were both investigated on single ventricular cell and the tissue. The experimental results demonstrated that the lower the IK1, the higher the automatic rhythm. The autorhythmicity increased with the decreasing of IK1. The tissue was controlled by the automatic rhythm when IK1 was less enough; in contrast, it was controlled by the sinus rhythm when IK1 was larger than a critical value.
AB - Inward-rectifier K+ current (IK1) is a major current in ventricular myocytes, which contributes both to the fourth phase of repolarization and setting the resting membrane potential. The down-regulation of IK1 could induce automaticity in human ventricular myocytes. An idealized 2D human ventricular tissue was designed in this paper, which was 100 cells in length and 400 cells in width. The effects of IK1 were both investigated on single ventricular cell and the tissue. The experimental results demonstrated that the lower the IK1, the higher the automatic rhythm. The autorhythmicity increased with the decreasing of IK1. The tissue was controlled by the automatic rhythm when IK1 was less enough; in contrast, it was controlled by the sinus rhythm when IK1 was larger than a critical value.
UR - https://www.scopus.com/pages/publications/84963998062
U2 - 10.1109/CIC.2015.7411108
DO - 10.1109/CIC.2015.7411108
M3 - 会议稿件
AN - SCOPUS:84963998062
T3 - Computing in Cardiology
SP - 1105
EP - 1108
BT - Computing in Cardiology Conference 2015, CinC 2015
A2 - Murray, Alan
PB - IEEE Computer Society
T2 - 42nd Computing in Cardiology Conference, CinC 2015
Y2 - 6 September 2015 through 9 September 2015
ER -