Simulation of ECG under ischemic condition in human ventricular tissue

In this study, we developed a 2D model of human left ventricular tissue based on the anatomical structure of human heart. Using the model, we explored the functional effects of ischemia-induced electrical properties of cardiac cells on ventricular electrical wave conduction. The ischemic model takes into account of three main pathophysiological consequences of ischemia that include hyperkalaemia, acidosis, and anoxia. The effects of ischemic level and size on the characteristics of ECG were quantified. It was shown that under ischemic conditions, the action potential durations of ventricular cells were abbreviated. And in most cases, the larger the size of ischemic region or the more severe the ischemic level, the more dramatic the changes in the amplitude of ST-T wave were observed.