Sequentially automated extraction of nucleic acids with magnetophoresis in microfluidic chips

A microfluidic platform is reported that utilizes magnetophoresis for the sequential and automated extraction of nucleic acid from biological samples. The system incorporates multiple microfluidic chips to process biological samples and extract nucleic acid using magnetic bead separation. The design is detailed, highlighting its efficiency and functionality. The injection pumps play a vital role in nucleic acid extraction by loading samples, cell lysis fluid, and magnetic nanoparticles into the microfluidic chips. These pumps enable the precise delivery of the required substances, allowing for efficient and effective extraction of nucleic acids. One embodiment of the microfluidic automated system provides a circuit design and implementation method. The programmable, fully automated system integrates various sensors and electronic components to enable efficient execution of the extraction process for multiple biomedical samples. The microfluidic system adopts a sequential automated process, enabling rapid delivery and minimizing the risk of sample contamination.