Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging

Jinqiao Dong; Yutong Pan; Heng Wang; Kuiwei Yang; Lingmei Liu; Zhiwei Qiao; Yi Di Yuan; Shing Bo Peh; Jian Zhang; Leilei Shi; Hong Liang; Yu Han; Xiaopeng Li; Jianwen Jiang; Bin Liu; Dan Zhao

doi:10.1002/anie.201915199

Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging

Jinqiao Dong
, Yutong Pan
, Heng Wang
, Kuiwei Yang
, Lingmei Liu
, Zhiwei Qiao
, Yi Di Yuan
, Shing Bo Peh
, Jian Zhang
, Leilei Shi
, Hong Liang
, Yu Han
, Xiaopeng Li
, Jianwen Jiang
, Bin Liu^*
, Dan Zhao

^*Corresponding author for this work

National University of Singapore
University of South Florida
King Abdullah University of Science and Technology
Guangzhou University

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

Abstract

The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2–10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

Original language	English
Pages (from-to)	10151-10159
Number of pages	9
Journal	Angewandte Chemie - International Edition
Volume	59
Issue number	25
DOIs	https://doi.org/10.1002/anie.201915199
State	Published - 15 Jun 2020
Externally published	Yes

Keywords

aggregation induced emission
coordination cages
live-cell imaging
molecular rotors
self-assembly

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10.1002/anie.201915199

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Dong, J., Pan, Y., Wang, H., Yang, K., Liu, L., Qiao, Z., Yuan, Y. D., Peh, S. B., Zhang, J., Shi, L., Liang, H., Han, Y., Li, X., Jiang, J., Liu, B., & Zhao, D. (2020). Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging. Angewandte Chemie - International Edition, 59(25), 10151-10159. https://doi.org/10.1002/anie.201915199

@article{cc5e539624a648c087c3acbc1f717708,

title = "Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging",

abstract = "The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2–10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.",

keywords = "aggregation induced emission, coordination cages, live-cell imaging, molecular rotors, self-assembly",

author = "Jinqiao Dong and Yutong Pan and Heng Wang and Kuiwei Yang and Lingmei Liu and Zhiwei Qiao and Yuan, \{Yi Di\} and Peh, \{Shing Bo\} and Jian Zhang and Leilei Shi and Hong Liang and Yu Han and Xiaopeng Li and Jianwen Jiang and Bin Liu and Dan Zhao",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2020",

month = jun,

day = "15",

doi = "10.1002/anie.201915199",

language = "英语",

volume = "59",

pages = "10151--10159",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "25",

}

Dong, J, Pan, Y, Wang, H, Yang, K, Liu, L, Qiao, Z, Yuan, YD, Peh, SB, Zhang, J, Shi, L, Liang, H, Han, Y, Li, X, Jiang, J, Liu, B & Zhao, D 2020, 'Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging', Angewandte Chemie - International Edition, vol. 59, no. 25, pp. 10151-10159. https://doi.org/10.1002/anie.201915199

TY - JOUR

T1 - Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging

AU - Dong, Jinqiao

AU - Pan, Yutong

AU - Wang, Heng

AU - Yang, Kuiwei

AU - Liu, Lingmei

AU - Qiao, Zhiwei

AU - Yuan, Yi Di

AU - Peh, Shing Bo

AU - Zhang, Jian

AU - Shi, Leilei

AU - Liang, Hong

AU - Han, Yu

AU - Li, Xiaopeng

AU - Jiang, Jianwen

AU - Liu, Bin

AU - Zhao, Dan

PY - 2020/6/15

Y1 - 2020/6/15

N2 - The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2–10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

AB - The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2–10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.

KW - aggregation induced emission

KW - coordination cages

KW - live-cell imaging

KW - molecular rotors

KW - self-assembly

UR - https://www.scopus.com/pages/publications/85078665289

U2 - 10.1002/anie.201915199

DO - 10.1002/anie.201915199

M3 - 文章

C2 - 31859381

AN - SCOPUS:85078665289

SN - 1433-7851

VL - 59

SP - 10151

EP - 10159

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 25

ER -

Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging

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Keywords

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