SARS-Cov-2 Damage on the Nervous System and Mental Health

Mohamed Said Boulkrane; Victoria Ilina; Roman Melchakov; Mikhail Arisov; Julia Fedotova; Lucia Gozzo; Filippo Drago; Weihong Lu; Alexey Sarapultsev; Vadim Tseilikman; Denis Baranenko

doi:10.2174/1570159X19666210629151303

SARS-Cov-2 Damage on the Nervous System and Mental Health

Mohamed Said Boulkrane
, Victoria Ilina
, Roman Melchakov
, Mikhail Arisov
, Julia Fedotova^*
, Lucia Gozzo
, Filippo Drago
, Weihong Lu
, Alexey Sarapultsev
, Vadim Tseilikman
, Denis Baranenko

^*Corresponding author for this work

Faculty of Life Sciences and Medicine

St. Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO)
a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”
I.P. Pavlov Institute of Physiology RASci
South Ural State University
University of Catania

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.

Original language	English
Pages (from-to)	412-431
Number of pages	20
Journal	Current Neuropharmacology
Volume	20
Issue number	2
DOIs	https://doi.org/10.2174/1570159X19666210629151303
State	Published - Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain disorders
COVID-19
Mental health
Neuroinvasive potential
Neurological diseases
SARS-CoV-2

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10.2174/1570159X19666210629151303

Cite this

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title = "SARS-Cov-2 Damage on the Nervous System and Mental Health",

abstract = "The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.",

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doi = "10.2174/1570159X19666210629151303",

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AU - Boulkrane, Mohamed Said

AU - Ilina, Victoria

AU - Melchakov, Roman

AU - Arisov, Mikhail

AU - Fedotova, Julia

AU - Gozzo, Lucia

AU - Drago, Filippo

AU - Lu, Weihong

AU - Sarapultsev, Alexey

AU - Tseilikman, Vadim

AU - Baranenko, Denis

PY - 2022/2

Y1 - 2022/2

N2 - The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.

AB - The World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.

KW - Brain disorders

KW - COVID-19

KW - Mental health

KW - Neuroinvasive potential

KW - Neurological diseases

KW - SARS-CoV-2

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DO - 10.2174/1570159X19666210629151303

M3 - 文献综述

C2 - 34191699

AN - SCOPUS:85125589893

SN - 1570-159X

VL - 20

SP - 412

EP - 431

JO - Current Neuropharmacology

JF - Current Neuropharmacology

IS - 2

ER -

SARS-Cov-2 Damage on the Nervous System and Mental Health

Abstract

UN SDGs

Keywords

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