Retraction:Interaction of Somatostatin receptor-2 and Neuropeptide y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model

Qiong Xiang; Chang Lin Wang; Shuo Song; Rui Jing

doi:10.1016/j.pbb.2013.02.001

Retraction:Interaction of Somatostatin receptor-2 and Neuropeptide y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model

Qiong Xiang^*
, Chang Lin Wang
, Shuo Song
, Rui Jing

^*Corresponding author for this work

School of Life Science and Technology, Harbin Institute of Technology
University of Freiburg
School of Management, Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of this paper was to evaluate the interactions of Somatostatin receptor-2 (SST2) and Neuropeptide Y receptors-1 (Y1) by molecular, pharmacological and behavioral studies. Double-immunolabeling of SST2 and Y1 has shown the colocalization of these two receptors in the dorsal root ganglion (DRG) neurons. On the basis of the Pinch nerve injury model, the mechanical hyperalgesia and severely painful behavior (autotomy) were detected after the application of SST2 antibody (anti-SST2; 200 μg/kg) on the pinch-injured nerve. The differential distribution of Y1 and up-regulation of PKC expression in DRGs were observed after anti-SST2 treatment. Our results indicated for the first time the interactions of SST2 and Y1 in DRGs, which have functional role in pain modulation and might give rise to explore possible novel therapeutic strategies against pain.

Original language	English
Pages (from-to)	71-75
Number of pages	5
Journal	Pharmacology Biochemistry and Behavior
Volume	105
DOIs	https://doi.org/10.1016/j.pbb.2013.02.001
State	Published - Apr 2013
Externally published	Yes

Keywords

Dorsal root ganglion DRG
Interaction
Neuropeptide Y receptors-1 Y1
Pinch-nerve injury
Somatostatin receptor-2 SST2

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10.1016/j.pbb.2013.02.001

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title = "Retraction:Interaction of Somatostatin receptor-2 and Neuropeptide y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model",

abstract = "The aim of this paper was to evaluate the interactions of Somatostatin receptor-2 (SST2) and Neuropeptide Y receptors-1 (Y1) by molecular, pharmacological and behavioral studies. Double-immunolabeling of SST2 and Y1 has shown the colocalization of these two receptors in the dorsal root ganglion (DRG) neurons. On the basis of the Pinch nerve injury model, the mechanical hyperalgesia and severely painful behavior (autotomy) were detected after the application of SST2 antibody (anti-SST2; 200 μg/kg) on the pinch-injured nerve. The differential distribution of Y1 and up-regulation of PKC expression in DRGs were observed after anti-SST2 treatment. Our results indicated for the first time the interactions of SST2 and Y1 in DRGs, which have functional role in pain modulation and might give rise to explore possible novel therapeutic strategies against pain.",

keywords = "Dorsal root ganglion DRG, Interaction, Neuropeptide Y receptors-1 Y1, Pinch-nerve injury, Somatostatin receptor-2 SST2",

author = "Qiong Xiang and Wang, \{Chang Lin\} and Shuo Song and Rui Jing",

year = "2013",

month = apr,

doi = "10.1016/j.pbb.2013.02.001",

language = "英语",

volume = "105",

pages = "71--75",

journal = "Pharmacology Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

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T1 - Retraction:Interaction of Somatostatin receptor-2 and Neuropeptide y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model

AU - Xiang, Qiong

AU - Wang, Chang Lin

AU - Song, Shuo

AU - Jing, Rui

PY - 2013/4

Y1 - 2013/4

N2 - The aim of this paper was to evaluate the interactions of Somatostatin receptor-2 (SST2) and Neuropeptide Y receptors-1 (Y1) by molecular, pharmacological and behavioral studies. Double-immunolabeling of SST2 and Y1 has shown the colocalization of these two receptors in the dorsal root ganglion (DRG) neurons. On the basis of the Pinch nerve injury model, the mechanical hyperalgesia and severely painful behavior (autotomy) were detected after the application of SST2 antibody (anti-SST2; 200 μg/kg) on the pinch-injured nerve. The differential distribution of Y1 and up-regulation of PKC expression in DRGs were observed after anti-SST2 treatment. Our results indicated for the first time the interactions of SST2 and Y1 in DRGs, which have functional role in pain modulation and might give rise to explore possible novel therapeutic strategies against pain.

AB - The aim of this paper was to evaluate the interactions of Somatostatin receptor-2 (SST2) and Neuropeptide Y receptors-1 (Y1) by molecular, pharmacological and behavioral studies. Double-immunolabeling of SST2 and Y1 has shown the colocalization of these two receptors in the dorsal root ganglion (DRG) neurons. On the basis of the Pinch nerve injury model, the mechanical hyperalgesia and severely painful behavior (autotomy) were detected after the application of SST2 antibody (anti-SST2; 200 μg/kg) on the pinch-injured nerve. The differential distribution of Y1 and up-regulation of PKC expression in DRGs were observed after anti-SST2 treatment. Our results indicated for the first time the interactions of SST2 and Y1 in DRGs, which have functional role in pain modulation and might give rise to explore possible novel therapeutic strategies against pain.

KW - Dorsal root ganglion DRG

KW - Interaction

KW - Neuropeptide Y receptors-1 Y1

KW - Pinch-nerve injury

KW - Somatostatin receptor-2 SST2

UR - https://www.scopus.com/pages/publications/84876062421

U2 - 10.1016/j.pbb.2013.02.001

DO - 10.1016/j.pbb.2013.02.001

M3 - 文章

C2 - 23402941

AN - SCOPUS:84876062421

SN - 0091-3057

VL - 105

SP - 71

EP - 75

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

ER -

Retraction:Interaction of Somatostatin receptor-2 and Neuropeptide y receptor-1 in mice dorsal root ganglion neurons on the Pinch-nerve injury model

Abstract

Keywords

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