Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease

Yao Sun; Ying Chun Zhang; Si Cong Tian; Bao Long Li; Yu Juan Shan

doi:10.3867/j.issn.1000-3002.2019.08.011

Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease

Yao Sun
, Ying Chun Zhang
, Si Cong Tian
, Bao Long Li
, Yu Juan Shan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The intervention of sulforaphane can reduce the risk of diabetes and its complications. It is mainly achieved by regulating nuclear factor erythroid-2-related factor 2 (Nrf2) to inhibit endothelial cell activation and improve high density lipoprotein levels. In addition, sulforaphane can bring about a marked improvement on fatty liver disease by regulating lipid metabolism. Its important pathways include the regulation of peroxisome proliferators-activated receptors y (PPARy), hormone-sensitive triglyceride lipase (HSL) and AMP-activated protein kinase (AMPK) regulation promotes lipolysis. In summary, further exploration of the mechanism of action of plant-derived functional ingredients of sulforaphane may be the key to preventing and treating diabetes and fatty liver disease.

Original language	English
Pages (from-to)	628-632
Number of pages	5
Journal	Chinese Journal of Pharmacology and Toxicology
Volume	33
Issue number	8
DOIs	https://doi.org/10.3867/j.issn.1000-3002.2019.08.011
State	Published - Aug 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Diabetes
Fatty liver disease
Phytochemicals
Sulforaphane

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10.3867/j.issn.1000-3002.2019.08.011

Cite this

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title = "Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease",

abstract = "The intervention of sulforaphane can reduce the risk of diabetes and its complications. It is mainly achieved by regulating nuclear factor erythroid-2-related factor 2 (Nrf2) to inhibit endothelial cell activation and improve high density lipoprotein levels. In addition, sulforaphane can bring about a marked improvement on fatty liver disease by regulating lipid metabolism. Its important pathways include the regulation of peroxisome proliferators-activated receptors y (PPARy), hormone-sensitive triglyceride lipase (HSL) and AMP-activated protein kinase (AMPK) regulation promotes lipolysis. In summary, further exploration of the mechanism of action of plant-derived functional ingredients of sulforaphane may be the key to preventing and treating diabetes and fatty liver disease.",

keywords = "Diabetes, Fatty liver disease, Phytochemicals, Sulforaphane",

author = "Yao Sun and Zhang, \{Ying Chun\} and Tian, \{Si Cong\} and Li, \{Bao Long\} and Shan, \{Yu Juan\}",

year = "2020",

month = aug,

doi = "10.3867/j.issn.1000-3002.2019.08.011",

language = "英语",

volume = "33",

pages = "628--632",

journal = "Chinese Journal of Pharmacology and Toxicology",

issn = "1000-3002",

publisher = "Chinese Journal of Pharmacology and Toxicology",

number = "8",

}

TY - JOUR

T1 - Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease

AU - Sun, Yao

AU - Zhang, Ying Chun

AU - Tian, Si Cong

AU - Li, Bao Long

AU - Shan, Yu Juan

PY - 2020/8

Y1 - 2020/8

N2 - The intervention of sulforaphane can reduce the risk of diabetes and its complications. It is mainly achieved by regulating nuclear factor erythroid-2-related factor 2 (Nrf2) to inhibit endothelial cell activation and improve high density lipoprotein levels. In addition, sulforaphane can bring about a marked improvement on fatty liver disease by regulating lipid metabolism. Its important pathways include the regulation of peroxisome proliferators-activated receptors y (PPARy), hormone-sensitive triglyceride lipase (HSL) and AMP-activated protein kinase (AMPK) regulation promotes lipolysis. In summary, further exploration of the mechanism of action of plant-derived functional ingredients of sulforaphane may be the key to preventing and treating diabetes and fatty liver disease.

AB - The intervention of sulforaphane can reduce the risk of diabetes and its complications. It is mainly achieved by regulating nuclear factor erythroid-2-related factor 2 (Nrf2) to inhibit endothelial cell activation and improve high density lipoprotein levels. In addition, sulforaphane can bring about a marked improvement on fatty liver disease by regulating lipid metabolism. Its important pathways include the regulation of peroxisome proliferators-activated receptors y (PPARy), hormone-sensitive triglyceride lipase (HSL) and AMP-activated protein kinase (AMPK) regulation promotes lipolysis. In summary, further exploration of the mechanism of action of plant-derived functional ingredients of sulforaphane may be the key to preventing and treating diabetes and fatty liver disease.

KW - Diabetes

KW - Fatty liver disease

KW - Phytochemicals

KW - Sulforaphane

UR - https://www.scopus.com/pages/publications/85094673101

U2 - 10.3867/j.issn.1000-3002.2019.08.011

DO - 10.3867/j.issn.1000-3002.2019.08.011

M3 - 文章

AN - SCOPUS:85094673101

SN - 1000-3002

VL - 33

SP - 628

EP - 632

JO - Chinese Journal of Pharmacology and Toxicology

JF - Chinese Journal of Pharmacology and Toxicology

IS - 8

ER -

Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease

Abstract

UN SDGs

Keywords

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