Research advance on the electrophysiological modeling and simulation of short QT syndrome

Multi-physical scale modeling for simulating the electrophysiological dynamics of the heart is rapidly evolving and has made significant progress in the last d ecade. In this paper, we briefly review the current development of cardiac modelin g field with a particular focus on the modeling of short QT(SQT)syndrome arising from gene mutations in cardiac potassium channels. Firstly, we introduce Denis No ble's definition on multi-physical scale modeling of cardiac systems at sub-c ellular, cellular, tissue and whole organ levels. Secondly, we describe quantities that have been used to characterize the functional impacts of SQT gene mutation s on the electrical activity of cardiac systems at cellular, tissue and whole org an levels. Then we review up-to-date research results on quantifying the functi onal impacts of three SQT gene mutations associated with potassium channels on t he genesis of cardiac arrhythmia that underlie cardiac sudden death. Finally we o utline possible research and application prospects of the electrophysiological m odeling and simulation of SQT syndrome in the future.