Relationship of common expression quantitative trait loci genes to the immune system

J. Li; L. Wang; H. Li; R. Zhang; X. Li; M. Guo

doi:10.4238/2013.December.11.6

Relationship of common expression quantitative trait loci genes to the immune system

J. Li
, L. Wang
, H. Li
, R. Zhang
, X. Li^*
, M. Guo

^*Corresponding author for this work

School of Life Science and Technology, Harbin Institute of Technology
School of Computer Science and Technology, Harbin Institute of Technology
Harbin Medical University

Research output: Contribution to journal › Article › peer-review

Abstract

Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 genes were validated using the Online Mendelian Inheritance in Man database, and the others were validated through text mining. Most of these disorders were related to the systemic immune system. In functional analyses using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes, these common eQTL genes were enriched in biological processes and pathways mostly related to the immunity. Therefore, we believe that these common eQTL genes are related to immune system.

Original language	English
Pages (from-to)	6546-6553
Number of pages	8
Journal	Genetics and Molecular Research
Volume	12
Issue number	4
DOIs	https://doi.org/10.4238/2013.December.11.6
State	Published - 11 Dec 2013
Externally published	Yes

Keywords

Expression quantitative trait locus
Immune system
Multiple tissues

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10.4238/2013.December.11.6

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AU - Li, J.

AU - Wang, L.

AU - Li, H.

AU - Zhang, R.

AU - Li, X.

AU - Guo, M.

PY - 2013/12/11

Y1 - 2013/12/11

N2 - Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 genes were validated using the Online Mendelian Inheritance in Man database, and the others were validated through text mining. Most of these disorders were related to the systemic immune system. In functional analyses using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes, these common eQTL genes were enriched in biological processes and pathways mostly related to the immunity. Therefore, we believe that these common eQTL genes are related to immune system.

AB - Tissue-specific expression quantitative trait loci (eQTLs) are always linked to specific diseases. In this study, we focused on eQTLs common to multiple tissues and explored their functional mechanisms in disease for the first time. We found 11 common eQTL genes among multiple tissues. Five genes were validated through a genome-wide association study, 3 genes were validated using the Online Mendelian Inheritance in Man database, and the others were validated through text mining. Most of these disorders were related to the systemic immune system. In functional analyses using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes, these common eQTL genes were enriched in biological processes and pathways mostly related to the immunity. Therefore, we believe that these common eQTL genes are related to immune system.

KW - Expression quantitative trait locus

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M3 - 文章

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Relationship of common expression quantitative trait loci genes to the immune system

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Keywords

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