Real-time monitoring of insulin using a graphene aptameric nanosensor

Zhuang Hao; Yibo Zhu; Xuejun Wang; Pavana Rotti; Christopher Dimarco; Shuyu Lin; Xuezeng Zhao; John Engelhardt; James Hone; Qiao Lin

doi:10.1109/MEMSYS.2017.7863425

Real-time monitoring of insulin using a graphene aptameric nanosensor

Zhuang Hao^*
, Yibo Zhu
, Xuejun Wang
, Pavana Rotti
, Christopher Dimarco
, Shuyu Lin
, Xuezeng Zhao
, John Engelhardt
, James Hone
, Qiao Lin

^*Corresponding author for this work

School of Mechatronics Engineering

Columbia University
Harbin Institute of Technology
University of Iowa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

We present a new approach for real-time, specific and sensitive detection of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a graphene field effect transistor, where the graphene conducting channel was functionalized with a guanine-rich aptamer IGA3 that would form an anti-parallel G-quadruplex upon insulin binding. The aptamer conformational changes altered the electrical conductance of graphene by varying the carrier density of the graphene. The nanosensor allowed us to perform real-time, label-free and specific detection of insulin concentrations as low as 1 nM.

Original language	English
Title of host publication	2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	398-401
Number of pages	4
ISBN (Electronic)	9781509050789
DOIs	https://doi.org/10.1109/MEMSYS.2017.7863425
State	Published - 23 Feb 2017
Event	30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States Duration: 22 Jan 2017 → 26 Jan 2017

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
Country/Territory	United States
City	Las Vegas
Period	22/01/17 → 26/01/17

Access to Document

10.1109/MEMSYS.2017.7863425

Cite this

Hao, Z., Zhu, Y., Wang, X., Rotti, P., Dimarco, C., Lin, S., Zhao, X., Engelhardt, J., Hone, J., & Lin, Q. (2017). Real-time monitoring of insulin using a graphene aptameric nanosensor. In 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017 (pp. 398-401). Article 7863425 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2017.7863425

Hao, Zhuang ; Zhu, Yibo ; Wang, Xuejun et al. / Real-time monitoring of insulin using a graphene aptameric nanosensor. 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 398-401 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

@inproceedings{e95d73ab606247c7a8f3abaa97292a55,

title = "Real-time monitoring of insulin using a graphene aptameric nanosensor",

abstract = "We present a new approach for real-time, specific and sensitive detection of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a graphene field effect transistor, where the graphene conducting channel was functionalized with a guanine-rich aptamer IGA3 that would form an anti-parallel G-quadruplex upon insulin binding. The aptamer conformational changes altered the electrical conductance of graphene by varying the carrier density of the graphene. The nanosensor allowed us to perform real-time, label-free and specific detection of insulin concentrations as low as 1 nM.",

author = "Zhuang Hao and Yibo Zhu and Xuejun Wang and Pavana Rotti and Christopher Dimarco and Shuyu Lin and Xuezeng Zhao and John Engelhardt and James Hone and Qiao Lin",

note = "Publisher Copyright: {\textcopyright} 2017 IEEE.; 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 ; Conference date: 22-01-2017 Through 26-01-2017",

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doi = "10.1109/MEMSYS.2017.7863425",

language = "英语",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

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Hao, Z, Zhu, Y, Wang, X, Rotti, P, Dimarco, C, Lin, S, Zhao, X, Engelhardt, J, Hone, J & Lin, Q 2017, Real-time monitoring of insulin using a graphene aptameric nanosensor. in 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017., 7863425, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., pp. 398-401, 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017, Las Vegas, United States, 22/01/17. https://doi.org/10.1109/MEMSYS.2017.7863425

Real-time monitoring of insulin using a graphene aptameric nanosensor. / Hao, Zhuang; Zhu, Yibo; Wang, Xuejun et al.
2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 398-401 7863425 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lin, Shuyu

AU - Zhao, Xuezeng

AU - Engelhardt, John

AU - Hone, James

AU - Lin, Qiao

PY - 2017/2/23

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N2 - We present a new approach for real-time, specific and sensitive detection of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a graphene field effect transistor, where the graphene conducting channel was functionalized with a guanine-rich aptamer IGA3 that would form an anti-parallel G-quadruplex upon insulin binding. The aptamer conformational changes altered the electrical conductance of graphene by varying the carrier density of the graphene. The nanosensor allowed us to perform real-time, label-free and specific detection of insulin concentrations as low as 1 nM.

AB - We present a new approach for real-time, specific and sensitive detection of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a graphene field effect transistor, where the graphene conducting channel was functionalized with a guanine-rich aptamer IGA3 that would form an anti-parallel G-quadruplex upon insulin binding. The aptamer conformational changes altered the electrical conductance of graphene by varying the carrier density of the graphene. The nanosensor allowed us to perform real-time, label-free and specific detection of insulin concentrations as low as 1 nM.

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Hao Z, Zhu Y, Wang X, Rotti P, Dimarco C, Lin S et al. Real-time monitoring of insulin using a graphene aptameric nanosensor. In 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017. Institute of Electrical and Electronics Engineers Inc. 2017. p. 398-401. 7863425. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2017.7863425

Real-time monitoring of insulin using a graphene aptameric nanosensor

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