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Rapid prototyping of microfluidic chips for use in droplet formation and Invitro Compartmentalisation

  • CSIRO

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The combined use of film transparency masks and dry film resist has allowed a rapid prototyping of designs and structures in chips for droplet generation. Patterning of the film resist has produced channels with smooth vertical sidewalls. The minimum feature dimension, ë, was reduced by increasing the resolution and spacing of the pattern geometries in the film mask. For a single layer of resist (~35 ?m thick), a minimum feature width of ~60 ?m was obtained using 2040 dpi transparency masks, 40 ?m for 5800 dpi transparency masks and 25 ?m using a Cr mask of equal size/ spacing of features. A doubling of the spacing between features in a 2400 dpi masks resulted in an attainable feature size of ~40 ?m. The minimum feature dimension increased exponentially with thickness of 5038 resist. Microfluidic chips which were fabricated in PMMA by this method have demonstrated controlled characteristics in the generation of oil droplets in water.

Original languageEnglish
Title of host publicationBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems
Pages72700K
DOIs
StatePublished - 2009
Externally publishedYes
EventBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems - Melbourne, VIC, Australia
Duration: 10 Dec 200812 Dec 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7270
ISSN (Print)1605-7422

Conference

ConferenceBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems
Country/TerritoryAustralia
CityMelbourne, VIC
Period10/12/0812/12/08

Keywords

  • Droplet generation
  • Dry Film resist
  • Microfluidic chip

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