Rapid determination of melatonin by droplet spray ionization mass spectrometry

Jie Jiang; Dongmei Zhang; Hong Zhang; Kai Yu; Jing He; Xiangnan Zhang; Na Li

doi:10.1016/j.ijms.2019.116191

Rapid determination of melatonin by droplet spray ionization mass spectrometry

Jie Jiang
, Dongmei Zhang
, Hong Zhang
, Kai Yu
, Jing He
, Xiangnan Zhang
, Na Li^*

^*Corresponding author for this work

School of Marine Science and Technology, Harbin Institute of Technology Weihai

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A new method based on droplet spray ionization mass spectrometry (DSI-MS) was developed for rapid qualitative and quantitative determination of melatonin products. Several different melatonin products were analysed with desvenlafaxine as internal standard. Samples only need to be dissolved and diluted without additional preparation procedures. The calibration curve was y=0.45692x−0.00538with the square of correlation coefficient (R²) of 0.9947 in the concentration range of 0.22–21.50 μM. The limit of detection (LOD) was 0.04 μM and limit of quantification (LOQ) was 0.17 μM, respectively. The recoveries were 88.4%–108.4% and the calculated RSDs were less than 12%. With this DSI-MS method, a single analysis can be completed within 1 min. This method inherent the advantages of rapid and accurate analysis, which can be used for qualitative and quantitative characterization of commercial melatonin products and quality control.

Original language	English
Article number	116191
Journal	International Journal of Mass Spectrometry
Volume	444
DOIs	https://doi.org/10.1016/j.ijms.2019.116191
State	Published - Oct 2019
Externally published	Yes

Keywords

Droplet spray ionization
Melatonin products
Qualitative
Quantitative
Rapid

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10.1016/j.ijms.2019.116191

Cite this

@article{260b8c9390194d67a14d4eb46a1c0b18,

title = "Rapid determination of melatonin by droplet spray ionization mass spectrometry",

abstract = "A new method based on droplet spray ionization mass spectrometry (DSI-MS) was developed for rapid qualitative and quantitative determination of melatonin products. Several different melatonin products were analysed with desvenlafaxine as internal standard. Samples only need to be dissolved and diluted without additional preparation procedures. The calibration curve was y=0.45692x−0.00538with the square of correlation coefficient (R2) of 0.9947 in the concentration range of 0.22–21.50 μM. The limit of detection (LOD) was 0.04 μM and limit of quantification (LOQ) was 0.17 μM, respectively. The recoveries were 88.4\%–108.4\% and the calculated RSDs were less than 12\%. With this DSI-MS method, a single analysis can be completed within 1 min. This method inherent the advantages of rapid and accurate analysis, which can be used for qualitative and quantitative characterization of commercial melatonin products and quality control.",

keywords = "Droplet spray ionization, Melatonin products, Qualitative, Quantitative, Rapid",

author = "Jie Jiang and Dongmei Zhang and Hong Zhang and Kai Yu and Jing He and Xiangnan Zhang and Na Li",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = oct,

doi = "10.1016/j.ijms.2019.116191",

language = "英语",

volume = "444",

journal = "International Journal of Mass Spectrometry",

issn = "1387-3806",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Rapid determination of melatonin by droplet spray ionization mass spectrometry

AU - Jiang, Jie

AU - Zhang, Dongmei

AU - Zhang, Hong

AU - Yu, Kai

AU - He, Jing

AU - Zhang, Xiangnan

AU - Li, Na

PY - 2019/10

Y1 - 2019/10

N2 - A new method based on droplet spray ionization mass spectrometry (DSI-MS) was developed for rapid qualitative and quantitative determination of melatonin products. Several different melatonin products were analysed with desvenlafaxine as internal standard. Samples only need to be dissolved and diluted without additional preparation procedures. The calibration curve was y=0.45692x−0.00538with the square of correlation coefficient (R2) of 0.9947 in the concentration range of 0.22–21.50 μM. The limit of detection (LOD) was 0.04 μM and limit of quantification (LOQ) was 0.17 μM, respectively. The recoveries were 88.4%–108.4% and the calculated RSDs were less than 12%. With this DSI-MS method, a single analysis can be completed within 1 min. This method inherent the advantages of rapid and accurate analysis, which can be used for qualitative and quantitative characterization of commercial melatonin products and quality control.

AB - A new method based on droplet spray ionization mass spectrometry (DSI-MS) was developed for rapid qualitative and quantitative determination of melatonin products. Several different melatonin products were analysed with desvenlafaxine as internal standard. Samples only need to be dissolved and diluted without additional preparation procedures. The calibration curve was y=0.45692x−0.00538with the square of correlation coefficient (R2) of 0.9947 in the concentration range of 0.22–21.50 μM. The limit of detection (LOD) was 0.04 μM and limit of quantification (LOQ) was 0.17 μM, respectively. The recoveries were 88.4%–108.4% and the calculated RSDs were less than 12%. With this DSI-MS method, a single analysis can be completed within 1 min. This method inherent the advantages of rapid and accurate analysis, which can be used for qualitative and quantitative characterization of commercial melatonin products and quality control.

KW - Droplet spray ionization

KW - Melatonin products

KW - Qualitative

KW - Quantitative

KW - Rapid

UR - https://www.scopus.com/pages/publications/85069704291

U2 - 10.1016/j.ijms.2019.116191

DO - 10.1016/j.ijms.2019.116191

M3 - 文章

AN - SCOPUS:85069704291

SN - 1387-3806

VL - 444

JO - International Journal of Mass Spectrometry

JF - International Journal of Mass Spectrometry

M1 - 116191

ER -

Rapid determination of melatonin by droplet spray ionization mass spectrometry

Abstract

Keywords

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