Rapid detection of diazepam injection based on surface enhanced Raman spectroscopy

Si Qin Gao Wa Han; Lin Bao; Mei Ling Zhang; Xiang Lin; Wu Li Ji Hasi

doi:10.2116/analsci.33.789

Rapid detection of diazepam injection based on surface enhanced Raman spectroscopy

Si Qin Gao Wa Han
, Lin Bao
, Mei Ling Zhang
, Xiang Lin
, Wu Li Ji Hasi^*

^*Corresponding author for this work

School of Astronautics

Inner Mongolia University for Nationalities
Harbin Institute of Technology
Dalian Minzu University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Diazepam injection was detected based on a droplet surface enhanced Raman spectroscopy (SERS) platform, which overcomes the disadvantages of the poor uniformity and time-consuming sample treatment process of the conventional "drop and dry" detection strategy. The Raman peak positions of diazepam injection were determined and identified, they are mainly located in the 689, 1002, 1170 and 1598 cm ^-1 , etc. Different concentrations of diazepam injection were detected. It was found that the intensity of 1002 cm ^-1 increases linearly with concentration in the range from 0.05 to 10 μg/mL and the linear correlation coefficient is 0.988. The limit of detection can reach 0.05 μg/mL. The SERS method is easy, fast and efficient. The results are accurate and reliable. It has favorable application potential in the detection of diazepam injection.

Original language	English
Pages (from-to)	789-792
Number of pages	4
Journal	Analytical Sciences
Volume	33
Issue number	7
DOIs	https://doi.org/10.2116/analsci.33.789
State	Published - 2017

Keywords

Aggregation agent
Diazepam injection
Silver colloid
Surface enhanced Raman spectroscopy

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10.2116/analsci.33.789

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title = "Rapid detection of diazepam injection based on surface enhanced Raman spectroscopy",

abstract = " Diazepam injection was detected based on a droplet surface enhanced Raman spectroscopy (SERS) platform, which overcomes the disadvantages of the poor uniformity and time-consuming sample treatment process of the conventional {"}drop and dry{"} detection strategy. The Raman peak positions of diazepam injection were determined and identified, they are mainly located in the 689, 1002, 1170 and 1598 cm -1 , etc. Different concentrations of diazepam injection were detected. It was found that the intensity of 1002 cm -1 increases linearly with concentration in the range from 0.05 to 10 μg/mL and the linear correlation coefficient is 0.988. The limit of detection can reach 0.05 μg/mL. The SERS method is easy, fast and efficient. The results are accurate and reliable. It has favorable application potential in the detection of diazepam injection.",

keywords = "Aggregation agent, Diazepam injection, Silver colloid, Surface enhanced Raman spectroscopy",

author = "Han, \{Si Qin Gao Wa\} and Lin Bao and Zhang, \{Mei Ling\} and Xiang Lin and Hasi, \{Wu Li Ji\}",

note = "Publisher Copyright: {\textcopyright} The Japan Society for Analytical Chemistry.",

year = "2017",

doi = "10.2116/analsci.33.789",

language = "英语",

volume = "33",

pages = "789--792",

journal = "Analytical Sciences",

issn = "0910-6340",

publisher = "Springer International Publishing AG",

number = "7",

}

TY - JOUR

T1 - Rapid detection of diazepam injection based on surface enhanced Raman spectroscopy

AU - Han, Si Qin Gao Wa

AU - Bao, Lin

AU - Zhang, Mei Ling

AU - Lin, Xiang

AU - Hasi, Wu Li Ji

N1 - Publisher Copyright: © The Japan Society for Analytical Chemistry.

PY - 2017

Y1 - 2017

N2 - Diazepam injection was detected based on a droplet surface enhanced Raman spectroscopy (SERS) platform, which overcomes the disadvantages of the poor uniformity and time-consuming sample treatment process of the conventional "drop and dry" detection strategy. The Raman peak positions of diazepam injection were determined and identified, they are mainly located in the 689, 1002, 1170 and 1598 cm -1 , etc. Different concentrations of diazepam injection were detected. It was found that the intensity of 1002 cm -1 increases linearly with concentration in the range from 0.05 to 10 μg/mL and the linear correlation coefficient is 0.988. The limit of detection can reach 0.05 μg/mL. The SERS method is easy, fast and efficient. The results are accurate and reliable. It has favorable application potential in the detection of diazepam injection.

AB - Diazepam injection was detected based on a droplet surface enhanced Raman spectroscopy (SERS) platform, which overcomes the disadvantages of the poor uniformity and time-consuming sample treatment process of the conventional "drop and dry" detection strategy. The Raman peak positions of diazepam injection were determined and identified, they are mainly located in the 689, 1002, 1170 and 1598 cm -1 , etc. Different concentrations of diazepam injection were detected. It was found that the intensity of 1002 cm -1 increases linearly with concentration in the range from 0.05 to 10 μg/mL and the linear correlation coefficient is 0.988. The limit of detection can reach 0.05 μg/mL. The SERS method is easy, fast and efficient. The results are accurate and reliable. It has favorable application potential in the detection of diazepam injection.

KW - Aggregation agent

KW - Diazepam injection

KW - Silver colloid

KW - Surface enhanced Raman spectroscopy

UR - https://www.scopus.com/pages/publications/85021951318

U2 - 10.2116/analsci.33.789

DO - 10.2116/analsci.33.789

M3 - 文章

C2 - 28690255

AN - SCOPUS:85021951318

SN - 0910-6340

VL - 33

SP - 789

EP - 792

JO - Analytical Sciences

JF - Analytical Sciences

IS - 7

ER -

Rapid detection of diazepam injection based on surface enhanced Raman spectroscopy

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