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Quantification of living cell adhesion forces with a nanorobotic system

  • Harbin Institute of Technology

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Cell-surface adhesion forces are significant in regulating cellular activities. In this paper, a nanorobotic system was developed and based on this system, a novel method measuring the cell-surface adhesion force is proposed. The nanorobotic system mainly consists of two independently actuated and sensed microcantilevers, forming a nanotweezer with capabilities of pick-and-place manipulation of a single cell in aqueous environments with accurate force sensing that is sufficiently sensitive to characterize interactions of cell-cell, cell-surface, even single molecules. Capabilities of the developed nanorobotic system have been validated by experimentally qualifying cell-surface adhesion events occurred between C2C12 cells (mouse adherent myoblasts) and Petri dishes under different contact time.

Original languageEnglish
Title of host publication2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2013 - Conference Proceedings
PublisherIEEE Computer Society
Pages44-48
Number of pages5
ISBN (Print)9781479912131
DOIs
StatePublished - 2013
Event2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2013 - Suzhou, China
Duration: 26 Aug 201330 Aug 2013

Publication series

Name2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2013 - Conference Proceedings

Conference

Conference2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2013
Country/TerritoryChina
CitySuzhou
Period26/08/1330/08/13

Keywords

  • C2C12 cells
  • Nanorobitc system
  • cell-surface adhesion
  • nanotweezer

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