Abstract
This paper reports on a water-soluble polysaccharide (AAP I-a) extracted from Auricularia auricular with assistance from ultrasonics, and purified by anion-exchange and gel-permeation chromatography. Additional further structural characteristics were determined from high-performance liquid chromatography/gel permeation chromatograph (HPLC/GPC), Fourier transform infrared (FT-IR) spectrometer and gas chromatography-mass spectrophotometer (GC-MS). AAP I-a is composed of l-rhamnose, l-arabinose, d-xylose, d-mannose, d-glucose, and d-galactose in a molar ratio of 0.2:2.6:0.4:3.6:1.0:0.4. After 35 days of AAP I-a oral administration (50, 100 and 200 mg/kg once a day), the AAP I-a significantly decreased the level of malondialdehyde (MDA) and increased superoxide dismutase (SOD) and glutathione (GSH) activities in mice where ageing is induced by d-galactose (p < 0.05). In conclusion, our results indicated that AAP I-a possessed potent antioxidant activity.
| Original language | English |
|---|---|
| Pages (from-to) | 638-648 |
| Number of pages | 11 |
| Journal | Carbohydrate Polymers |
| Volume | 84 |
| Issue number | 1 |
| DOIs | |
| State | Published - 11 Feb 2011 |
Keywords
- Ageing mouse model
- Auricularia auricula-judae
- Oxidative stress
- Polysaccharide
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