Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Li Tao; Xiaomeng Ren; Wenhui Zhai; Zheng Chen

doi:10.3390/molecules27134275

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Li Tao
, Xiaomeng Ren^*
, Wenhui Zhai
, Zheng Chen

^*Corresponding author for this work

PLA No. 305 Hospital
Shenyang Institute of Chemical Technology
School of Life Science and Technology, Harbin Institute of Technology

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physi-ological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an essential role in hyperglycemia, non-alcoholic fatty liver disease, alcoholic liver disease, liver regeneration, liver injury, autoimmune liver disease, viral hepatitis, and hepatocellular carcinoma. Small-molecule inhibitors targeting to non-canonical NF-κB signaling pathway have been developed and shown promising results in the treatment of liver injuries. Here, the recent advances and future prospects in understanding the roles of the non-canonical NF-κB signaling pathways in the regulation of liver diseases are discussed.

Original language	English
Article number	4275
Journal	Molecules
Volume	27
Issue number	13
DOIs	https://doi.org/10.3390/molecules27134275
State	Published - 1 Jul 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

NF-κB-inducing kinase
NF-κB2
liver diseases
metabolism
non-canonical NF-κB signaling pathway

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10.3390/molecules27134275

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title = "Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases",

abstract = "Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physi-ological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an essential role in hyperglycemia, non-alcoholic fatty liver disease, alcoholic liver disease, liver regeneration, liver injury, autoimmune liver disease, viral hepatitis, and hepatocellular carcinoma. Small-molecule inhibitors targeting to non-canonical NF-κB signaling pathway have been developed and shown promising results in the treatment of liver injuries. Here, the recent advances and future prospects in understanding the roles of the non-canonical NF-κB signaling pathways in the regulation of liver diseases are discussed.",

keywords = "NF-κB-inducing kinase, NF-κB2, liver diseases, metabolism, non-canonical NF-κB signaling pathway",

author = "Li Tao and Xiaomeng Ren and Wenhui Zhai and Zheng Chen",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

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doi = "10.3390/molecules27134275",

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T1 - Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

AU - Tao, Li

AU - Ren, Xiaomeng

AU - Zhai, Wenhui

AU - Chen, Zheng

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physi-ological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an essential role in hyperglycemia, non-alcoholic fatty liver disease, alcoholic liver disease, liver regeneration, liver injury, autoimmune liver disease, viral hepatitis, and hepatocellular carcinoma. Small-molecule inhibitors targeting to non-canonical NF-κB signaling pathway have been developed and shown promising results in the treatment of liver injuries. Here, the recent advances and future prospects in understanding the roles of the non-canonical NF-κB signaling pathways in the regulation of liver diseases are discussed.

AB - Non-canonical nuclear factor kappa B (NF-κB) signaling pathway regulates many physi-ological and pathological processes, including liver homeostasis and diseases. Recent studies demonstrate that non-canonical NF-κB signaling pathway plays an essential role in hyperglycemia, non-alcoholic fatty liver disease, alcoholic liver disease, liver regeneration, liver injury, autoimmune liver disease, viral hepatitis, and hepatocellular carcinoma. Small-molecule inhibitors targeting to non-canonical NF-κB signaling pathway have been developed and shown promising results in the treatment of liver injuries. Here, the recent advances and future prospects in understanding the roles of the non-canonical NF-κB signaling pathways in the regulation of liver diseases are discussed.

KW - NF-κB-inducing kinase

KW - NF-κB2

KW - liver diseases

KW - metabolism

KW - non-canonical NF-κB signaling pathway

UR - https://www.scopus.com/pages/publications/85133469500

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DO - 10.3390/molecules27134275

M3 - 文献综述

C2 - 35807520

AN - SCOPUS:85133469500

SN - 1420-3049

VL - 27

JO - Molecules

JF - Molecules

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M1 - 4275

ER -

Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases

Abstract

UN SDGs

Keywords

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