Prediction of Human Disease Genes Based on Associations between Phenome and Proteins

Guangri Quan; Yu Du; Junheng Huang; Yadong Wang

doi:10.1109/BMEI.2009.5301815

Prediction of Human Disease Genes Based on Associations between Phenome and Proteins

Guangri Quan^*
, Yu Du
, Junheng Huang
, Yadong Wang

^*Corresponding author for this work

Harbin Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical model reflects the regularity of associations between similarities of phenotypes and interactions of proteins. It can discribe the real biological systems better than traditional models, and gives a stronger predictive ability.

Original language	English
Title of host publication	Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
DOIs	https://doi.org/10.1109/BMEI.2009.5301815
State	Published - 2009
Event	2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 - Tianjin, China Duration: 17 Oct 2009 → 19 Oct 2009

Publication series

Name	Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

Conference

Conference	2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
Country/Territory	China
City	Tianjin
Period	17/10/09 → 19/10/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Disease gene
Disease phenotypic overlap
Protein-protein interactions

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10.1109/BMEI.2009.5301815

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Quan, G., Du, Y., Huang, J., & Wang, Y. (2009). Prediction of Human Disease Genes Based on Associations between Phenome and Proteins. In Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 Article 5301815 (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009). https://doi.org/10.1109/BMEI.2009.5301815

@inproceedings{d675c6cccca6497fbb8658bfaee7b05c,

title = "Prediction of Human Disease Genes Based on Associations between Phenome and Proteins",

abstract = "Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical model reflects the regularity of associations between similarities of phenotypes and interactions of proteins. It can discribe the real biological systems better than traditional models, and gives a stronger predictive ability.",

keywords = "Disease gene, Disease phenotypic overlap, Protein-protein interactions",

author = "Guangri Quan and Yu Du and Junheng Huang and Yadong Wang",

year = "2009",

doi = "10.1109/BMEI.2009.5301815",

language = "英语",

isbn = "9781424441341",

series = "Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009",

booktitle = "Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009",

note = "2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 ; Conference date: 17-10-2009 Through 19-10-2009",

}

Quan, G, Du, Y, Huang, J & Wang, Y 2009, Prediction of Human Disease Genes Based on Associations between Phenome and Proteins. in Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009., 5301815, Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009, Tianjin, China, 17/10/09. https://doi.org/10.1109/BMEI.2009.5301815

Prediction of Human Disease Genes Based on Associations between Phenome and Proteins. / Quan, Guangri; Du, Yu; Huang, Junheng et al.
Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009. 2009. 5301815 (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Prediction of Human Disease Genes Based on Associations between Phenome and Proteins

AU - Quan, Guangri

AU - Du, Yu

AU - Huang, Junheng

AU - Wang, Yadong

PY - 2009

Y1 - 2009

N2 - Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical model reflects the regularity of associations between similarities of phenotypes and interactions of proteins. It can discribe the real biological systems better than traditional models, and gives a stronger predictive ability.

AB - Disease genes identification is the key to the issue of human genetic diseases cure. This paper describes a new method of human genetic disease gene prediction, which is based on the relations between clinical manifestations and protein-protein interaction network. A new prediction model which is based on associated probability and Pearson correlation coefficient is also described. This mathematical model reflects the regularity of associations between similarities of phenotypes and interactions of proteins. It can discribe the real biological systems better than traditional models, and gives a stronger predictive ability.

KW - Disease gene

KW - Disease phenotypic overlap

KW - Protein-protein interactions

UR - https://www.scopus.com/pages/publications/74049152350

U2 - 10.1109/BMEI.2009.5301815

DO - 10.1109/BMEI.2009.5301815

M3 - 会议稿件

AN - SCOPUS:74049152350

SN - 9781424441341

T3 - Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

BT - Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

T2 - 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009

Y2 - 17 October 2009 through 19 October 2009

ER -

Quan G, Du Y, Huang J , Wang Y. Prediction of Human Disease Genes Based on Associations between Phenome and Proteins. In Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009. 2009. 5301815. (Proceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009). doi: 10.1109/BMEI.2009.5301815

Prediction of Human Disease Genes Based on Associations between Phenome and Proteins

Abstract

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Conference

UN SDGs

Keywords

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