PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

Fan Chen; Yan Zhang; Longcai Wang; Tao Wang; Zhifa Han; Haihua Zhang; Shan Gao; Yang Hu; Guiyou Liu

doi:10.3233/JAD-201140

PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

Fan Chen
, Yan Zhang
, Longcai Wang
, Tao Wang
, Zhifa Han
, Haihua Zhang
, Shan Gao
, Yang Hu^*
, Guiyou Liu^*

^*Corresponding author for this work

Capital Medical University
Weifang Medical University
Peking University
Chinese Institute for Brain Research
Tsinghua University
Chinese Academy of Medical Sciences
School of Life Science and Technology, Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer’s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59–0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

Original language	English
Pages (from-to)	71-77
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	80
Issue number	1
DOIs	https://doi.org/10.3233/JAD-201140
State	Published - 9 Mar 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer’s disease
PLCG2
genome-wide association study
multiple sclerosis
rs72824905 variant

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10.3233/JAD-201140

Cite this

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title = "PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer{\textquoteright}s Disease and Multiple Sclerosis",

abstract = "We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer{\textquoteright}s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95\% CI 0.59{\textendash}0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.",

keywords = "Alzheimer{\textquoteright}s disease, PLCG2, genome-wide association study, multiple sclerosis, rs72824905 variant",

author = "Fan Chen and Yan Zhang and Longcai Wang and Tao Wang and Zhifa Han and Haihua Zhang and Shan Gao and Yang Hu and Guiyou Liu",

year = "2021",

month = mar,

day = "9",

doi = "10.3233/JAD-201140",

language = "英语",

volume = "80",

pages = "71--77",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

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}

TY - JOUR

T1 - PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

AU - Chen, Fan

AU - Zhang, Yan

AU - Wang, Longcai

AU - Wang, Tao

AU - Han, Zhifa

AU - Zhang, Haihua

AU - Gao, Shan

AU - Hu, Yang

AU - Liu, Guiyou

PY - 2021/3/9

Y1 - 2021/3/9

N2 - We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer’s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59–0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

AB - We aimed to evaluate the association of PLCG2 rs72824905 variant with Alzheimer’s disease (AD) and multiple sclerosis (MS) using large-scale genetic association study datasets. We selected 50,024 AD cases and 467,330 controls, and 32,367 MS cases and 36,012 controls. We found moderate heterogeneity of rs72824905 in different studies. We found significant association between rs72824905 G allele and reduced AD risk (OR = 0.66, 95% CI 0.59–0.74, p = 5.91E-14). Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent.

KW - Alzheimer’s disease

KW - PLCG2

KW - genome-wide association study

KW - multiple sclerosis

KW - rs72824905 variant

UR - https://www.scopus.com/pages/publications/85102964444

U2 - 10.3233/JAD-201140

DO - 10.3233/JAD-201140

M3 - 文章

C2 - 33523007

AN - SCOPUS:85102964444

SN - 1387-2877

VL - 80

SP - 71

EP - 77

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis

Abstract

UN SDGs

Keywords

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