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Photoacoustic computed tomography guided microrobots for targeted navigation in intestines in vivo

  • Lei Li
  • , Zhiguang Wu
  • , Yiran Yang
  • , Peng Hu
  • , Wei Gao*
  • , Lihong V. Wang
  • *Corresponding author for this work
  • California Institute of Technology

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Tremendous progress in synthetic micro/nanomotors has been made for potential biomedical applications. However, existing micro/nanomotor platforms are inefficient for deep tissue imaging and motion control in vivo. Here, we present a photoacoustic computed tomography (PACT) guided investigation of micromotors in intestines in vivo. The micromotors enveloped in microcapsules exhibit efficient propulsion in various biofluids once released. PACT has visualized the migration of micromotor capsules toward the targeted regions in real time in vivo. The integration of the developed microrobotic system and PACT enables deep imaging and precise control of the micromotors in vivo.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2020
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510632431
DOIs
StatePublished - 2020
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2020 - San Francisco, United States
Duration: 2 Feb 20205 Feb 2020

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11240
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2020
Country/TerritoryUnited States
CitySan Francisco
Period2/02/205/02/20

Keywords

  • In vivo navigation
  • Microrobots
  • Photoacoustic computed tomography

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