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Pathogenic gene prediction based on network embedding

  • School of Computer Science and Technology, Harbin Institute of Technology
  • Beijing University of Civil Engineering and Architecture

Research output: Contribution to journalArticlepeer-review

Abstract

In disease research, the study of gene-disease correlation has always been an important topic. With the emergence of large-scale connected data sets in biology, we use known correlations between the entities, which may be from different sets, to build a biological heterogeneous network and propose a new network embedded representation algorithm to calculate the correlation between disease and genes, using the correlation score to predict pathogenic genes. Then, we conduct several experiments to compare our method to other state-of-the-art methods. The results reveal that our method achieves better performance than the traditional methods.

Original languageEnglish
Article numberbbaa353
JournalBriefings in Bioinformatics
Volume22
Issue number4
DOIs
StatePublished - 1 Jul 2021
Externally publishedYes

Keywords

  • biological computing
  • heterogeneous network embedding
  • pathogenic gene prediction

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