@inbook{4f653ed4e9aa4bf18ff7201c59f67a16,
title = "Optimisation of Maintenance Planning into the Production of Biopharmaceuticals with Performance Decay using a Continuous-time Formulation",
abstract = "This paper presents a mixed integer linear programing (MILP) model, based on a continuous-time Resource Task Network (RTN) formulation, for the optimal planning/scheduling of biopharmaceutical processes. The model proposes the integration of the production planning with the required downstream maintenance operations, due to performance decay. The model is applied to a literature-based midterm planning problem in the biopharmaceutical industry, addressing the main bioprocesses regulations. Results demonstrate the advantages of a continuous-time formulation to determine the optimal schedule solution and the benefit of incorporating maintenance operation decisions into production planning.",
keywords = "maintenance planning, optimisation, performance decay",
author = "Miguel Vieira and Songsong Liu and T{\^a}nia Pinto-Varela and Barbosa-P{\'o}voa, \{Ana P.\} and Papageorgiou, \{Lazaros G.\}",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",
year = "2016",
doi = "10.1016/B978-0-444-63428-3.50296-4",
language = "英语",
isbn = "9780444634283",
series = "Computer Aided Chemical Engineering",
publisher = "Elsevier B.V.",
pages = "1749--1754",
editor = "Zdravko Kravanja and Milos Bogataj",
booktitle = "26 European Symposium on Computer Aided Process Engineering, 2016",
address = "荷兰",
}