On-Site Periodontitis Diagnosis via Room-Temperature Oral Exhalation H2S Sensor Based on Yb-Doped Bi2S3 Nanoribbon

Ping Guo; Kai Wang; Xuyang An; Xuanyu Ren; Xinxin He; Yinhua Hu; Lijie Zhou; Guohua Cai; Lifeng Wang; Tiezhu Liu; Wenyu Ge; Jia Zhang

doi:10.1007/s40820-026-02273-x

On-Site Periodontitis Diagnosis via Room-Temperature Oral Exhalation H₂S Sensor Based on Yb-Doped Bi₂S₃ Nanoribbon

Ping Guo
, Kai Wang
, Xuyang An
, Xuanyu Ren
, Xinxin He
, Yinhua Hu
, Lijie Zhou
, Guohua Cai
, Lifeng Wang
, Tiezhu Liu^*
, Wenyu Ge^*
, Jia Zhang^*

^*Corresponding author for this work

School of Mechatronics Engineering

Harbin Institute of Technology
Heilongjiang Provincial Hospital
Northeast Forestry University
Harbin University of Science and Technology
The Second Affiliated Hospital of Harbin Medical University
Royal Melbourne Institute of Technology University

Research output: Contribution to journal › Article › peer-review

Abstract

H₂S gas in oral exhalation is a critical biomarker for early periodontitis diagnosis, yet practical on-site detection via portable sensors remains challenging. Herein, we report a room-temperature H₂S sensor based on CAU-17-derived Yb-doped Bi₂S₃ (Yb-Bi₂S₃) nanoribbons for rapid periodontitis screening. The sensor exhibits segmented linearity ranging from 5 ppb to 5 ppm, with a 3.31 response at 100 ppb, 11 s response time, and superior selectivity. Mechanism analysis combined with density functional theory calculations demonstrates that the superior detection performance originates from Yb doping-induced lattice distortion in Bi₂S₃, which enhances oxygen anion formation and specific H₂S adsorption capability. Notably, the sensor quantifies H₂S production from cultured Porphyromonas gingivalis, corroborating the correlation between oral pathogens, H₂S, and periodontitis. Additionally, it effectively discriminates exhaled H₂S levels on-site between healthy individuals and periodontitis patients in clinical validation. This work provides a promising platform for sensitive biomarker detection, paving the way for advanced intelligent medical diagnostics. (Figure presented.)

Original language	English
Article number	430
Journal	Nano-Micro Letters
Volume	18
Issue number	1
DOIs	https://doi.org/10.1007/s40820-026-02273-x
State	Published - Dec 2026

Keywords

HS sensor
On-site
Oral exhalation
Periodontitis diagnosis
Yb-doped BiS nanoribbon

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10.1007/s40820-026-02273-x

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title = "On-Site Periodontitis Diagnosis via Room-Temperature Oral Exhalation H2S Sensor Based on Yb-Doped Bi2S3 Nanoribbon",

abstract = "H2S gas in oral exhalation is a critical biomarker for early periodontitis diagnosis, yet practical on-site detection via portable sensors remains challenging. Herein, we report a room-temperature H2S sensor based on CAU-17-derived Yb-doped Bi2S3 (Yb-Bi2S3) nanoribbons for rapid periodontitis screening. The sensor exhibits segmented linearity ranging from 5 ppb to 5 ppm, with a 3.31 response at 100 ppb, 11 s response time, and superior selectivity. Mechanism analysis combined with density functional theory calculations demonstrates that the superior detection performance originates from Yb doping-induced lattice distortion in Bi2S3, which enhances oxygen anion formation and specific H2S adsorption capability. Notably, the sensor quantifies H2S production from cultured Porphyromonas gingivalis, corroborating the correlation between oral pathogens, H2S, and periodontitis. Additionally, it effectively discriminates exhaled H2S levels on-site between healthy individuals and periodontitis patients in clinical validation. This work provides a promising platform for sensitive biomarker detection, paving the way for advanced intelligent medical diagnostics. (Figure presented.)",

keywords = "HS sensor, On-site, Oral exhalation, Periodontitis diagnosis, Yb-doped BiS nanoribbon",

author = "Ping Guo and Kai Wang and Xuyang An and Xuanyu Ren and Xinxin He and Yinhua Hu and Lijie Zhou and Guohua Cai and Lifeng Wang and Tiezhu Liu and Wenyu Ge and Jia Zhang",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2026.",

year = "2026",

month = dec,

doi = "10.1007/s40820-026-02273-x",

language = "英语",

volume = "18",

journal = "Nano-Micro Letters",

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publisher = "Springer Science and Business Media B.V.",

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T1 - On-Site Periodontitis Diagnosis via Room-Temperature Oral Exhalation H2S Sensor Based on Yb-Doped Bi2S3 Nanoribbon

AU - Guo, Ping

AU - Wang, Kai

AU - An, Xuyang

AU - Ren, Xuanyu

AU - He, Xinxin

AU - Hu, Yinhua

AU - Zhou, Lijie

AU - Cai, Guohua

AU - Wang, Lifeng

AU - Liu, Tiezhu

AU - Ge, Wenyu

AU - Zhang, Jia

PY - 2026/12

Y1 - 2026/12

N2 - H2S gas in oral exhalation is a critical biomarker for early periodontitis diagnosis, yet practical on-site detection via portable sensors remains challenging. Herein, we report a room-temperature H2S sensor based on CAU-17-derived Yb-doped Bi2S3 (Yb-Bi2S3) nanoribbons for rapid periodontitis screening. The sensor exhibits segmented linearity ranging from 5 ppb to 5 ppm, with a 3.31 response at 100 ppb, 11 s response time, and superior selectivity. Mechanism analysis combined with density functional theory calculations demonstrates that the superior detection performance originates from Yb doping-induced lattice distortion in Bi2S3, which enhances oxygen anion formation and specific H2S adsorption capability. Notably, the sensor quantifies H2S production from cultured Porphyromonas gingivalis, corroborating the correlation between oral pathogens, H2S, and periodontitis. Additionally, it effectively discriminates exhaled H2S levels on-site between healthy individuals and periodontitis patients in clinical validation. This work provides a promising platform for sensitive biomarker detection, paving the way for advanced intelligent medical diagnostics. (Figure presented.)

AB - H2S gas in oral exhalation is a critical biomarker for early periodontitis diagnosis, yet practical on-site detection via portable sensors remains challenging. Herein, we report a room-temperature H2S sensor based on CAU-17-derived Yb-doped Bi2S3 (Yb-Bi2S3) nanoribbons for rapid periodontitis screening. The sensor exhibits segmented linearity ranging from 5 ppb to 5 ppm, with a 3.31 response at 100 ppb, 11 s response time, and superior selectivity. Mechanism analysis combined with density functional theory calculations demonstrates that the superior detection performance originates from Yb doping-induced lattice distortion in Bi2S3, which enhances oxygen anion formation and specific H2S adsorption capability. Notably, the sensor quantifies H2S production from cultured Porphyromonas gingivalis, corroborating the correlation between oral pathogens, H2S, and periodontitis. Additionally, it effectively discriminates exhaled H2S levels on-site between healthy individuals and periodontitis patients in clinical validation. This work provides a promising platform for sensitive biomarker detection, paving the way for advanced intelligent medical diagnostics. (Figure presented.)

KW - HS sensor

KW - On-site

KW - Oral exhalation

KW - Periodontitis diagnosis

KW - Yb-doped BiS nanoribbon

UR - https://www.scopus.com/pages/publications/105043973478

U2 - 10.1007/s40820-026-02273-x

DO - 10.1007/s40820-026-02273-x

M3 - 文章

AN - SCOPUS:105043973478

SN - 2311-6706

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JO - Nano-Micro Letters

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ER -

On-Site Periodontitis Diagnosis via Room-Temperature Oral Exhalation H₂S Sensor Based on Yb-Doped Bi₂S₃ Nanoribbon

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Keywords

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