Novel electrochemical sensing platform based on integration of molecularly imprinted polymer with Au@Ag hollow nanoshell for determination of resveratrol

An electrochemical sensor is developed based on molecularly imprinted polymer (MIP) and Au@Ag hollow nanoshell modified indium tin oxide (ITO) electrodes (MIP/Au@Ag/ITO) for resveratrol (Res) determination. Au@Ag bimetallic hollow nanoshells were prepared by electrodeposition, and followed with a simple replacement reaction. A layer of MIP was then synthesized in situ on the Au@Ag surface by electro-polymerization, with Res acting as template molecule and o-phenylenediamine as functional monomer. Hexacyanoferrate was used as electrochemical probe to generate signals, and the electrochemical behaviors of Res-MIP/Au@Ag/ITO were explored by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). A linear range from 2.0 × 10⁻¹¹ to 9.0 × 10⁻⁹ M for measuring Res was obtained, with a low detection limit of 7.1 × 10⁻¹² M (S/N = 3). With good stability and selectivity, this newly developed sensor has been successfully applied to Res measurement in grape seed extract.