Non-contact submicroliter liquid dispensing system with parameter adjustment function

An non-contact submicroliter liquid dispensing system with parameter adjustment function was developed.The system used a solenoid valve to control fluid flow to realize the noncontact reagent dispensing by opening and closing a valve and altering opening time and flow rate.By combining the advantages of non-contact solenoid-based technology with the robustness and flexibility of traditional liquid handlers, a novel high-speed flow MEMS sensor was proposed, it is characterized by robustness, repetition, flexibility and low-volume dispensing for samples with different properties. The experimental results indicate that the dispense reproducibility (Coefficient of Variance, CV) of the proposed system is lower than 3% at dispensing volume of 1 μl, and approach to 8% at dispensing volume of 50 nl, which can satisfy the requirements of dispensing submicroliter reagents in different viscosities, repetitions, flexibilities and reliabilities.