Nickel-catalyzed diastereoselective alkyl-alkyl kumada coupling reactions

Pablo M. Perez Garcia; Thomas Di Franco; Alessio Orsino; Peng Ren; Xile Hu

doi:10.1021/ol302067b

Nickel-catalyzed diastereoselective alkyl-alkyl kumada coupling reactions

Pablo M. Perez Garcia
, Thomas Di Franco
, Alessio Orsino
, Peng Ren
, Xile Hu^*

^*Corresponding author for this work

Swiss Federal Institute of Technology Lausanne

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

A nickel pincer complex is found to catalyze alkyl-alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides evidence that the activation of alkyl halides is reversible.

Original language	English
Pages (from-to)	4286-4289
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	16
DOIs	https://doi.org/10.1021/ol302067b
State	Published - 17 Aug 2012
Externally published	Yes

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10.1021/ol302067b

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@article{fee7ec2dc9a84193ad8a53cd7024973e,

title = "Nickel-catalyzed diastereoselective alkyl-alkyl kumada coupling reactions",

abstract = "A nickel pincer complex is found to catalyze alkyl-alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides evidence that the activation of alkyl halides is reversible.",

author = "\{Perez Garcia\}, \{Pablo M.\} and \{Di Franco\}, Thomas and Alessio Orsino and Peng Ren and Xile Hu",

year = "2012",

month = aug,

day = "17",

doi = "10.1021/ol302067b",

language = "英语",

volume = "14",

pages = "4286--4289",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "16",

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TY - JOUR

T1 - Nickel-catalyzed diastereoselective alkyl-alkyl kumada coupling reactions

AU - Perez Garcia, Pablo M.

AU - Di Franco, Thomas

AU - Orsino, Alessio

AU - Ren, Peng

AU - Hu, Xile

PY - 2012/8/17

Y1 - 2012/8/17

N2 - A nickel pincer complex is found to catalyze alkyl-alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides evidence that the activation of alkyl halides is reversible.

AB - A nickel pincer complex is found to catalyze alkyl-alkyl Kumada coupling reactions of 1,3- and 1,4-substituted cyclohexyl halides and tetrahydropyrans with an excellent diastereoselectivity. The mechanistic investigation of the coupling reactions provides evidence that the activation of alkyl halides is reversible.

UR - https://www.scopus.com/pages/publications/84865245127

U2 - 10.1021/ol302067b

DO - 10.1021/ol302067b

M3 - 文章

AN - SCOPUS:84865245127

SN - 1523-7060

VL - 14

SP - 4286

EP - 4289

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

Nickel-catalyzed diastereoselective alkyl-alkyl kumada coupling reactions

Abstract

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