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Neural network model assisted Fourier ptychography with Zernike aberration recovery and total variation constraint

  • Yongbing Zhang
  • , Yangzhe Liu
  • , Shaowei Jiang
  • , Krishna Dixit
  • , Pengming Song
  • , Xinfeng Zhang
  • , Xiangyang Ji
  • , Xiu Li*
  • *Corresponding author for this work
  • Tsinghua University
  • Harbin Institute of Technology Shenzhen
  • University of Connecticut
  • University of Chinese Academy of Sciences

Research output: Contribution to journalArticlepeer-review

Abstract

Significance: Fourier ptychography (FP) is a computational imaging approach that achieves high-resolution reconstruction. Inspired by neural networks, many deep-learning-based methods are proposed to solve FP problems. However, the performance of FP still suffers from optical aberration, which needs to be considered. Aim: We present a neural network model for FP reconstructions that can make proper estimation toward aberration and achieve artifact-free reconstruction. Approach: Inspired by the iterative reconstruction of FP, we design a neural network model that mimics the forward imaging process of FP via TensorFlow. The sample and aberration are considered as learnable weights and optimized through back-propagation. Especially, we employ the Zernike terms instead of aberration to decrease the optimization freedom of pupil recovery and perform a high-accuracy estimation. Owing to the auto-differentiation capabilities of the neural network, we additionally utilize total variation regularization to improve the visual quality. Results: We validate the performance of the reported method via both simulation and experiment. Our method exhibits higher robustness against sophisticated optical aberrations and achieves better image quality by reducing artifacts. Conclusions: The forward neural network model can jointly recover the high-resolution sample and optical aberration in iterative FP reconstruction. We hope our method that can provide a neural-network perspective to solve iterative-based coherent or incoherent imaging problems.

Original languageEnglish
Article number036502
JournalJournal of Biomedical Optics
Volume26
Issue number3
DOIs
StatePublished - 1 Mar 2021
Externally publishedYes

Keywords

  • Fourier ptychographic microscopy
  • neural network
  • optics
  • pupil recovery

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