Multimodal Synergistic Antimicrobial Activity of the Copper-Doped and Oxygen-Defective In Situ Nanocoating on Medical Titanium

Leizi Chi; Jinteng Qi; Zhuo Ma; Zeshuai Zhang; Yunfeng Qiu; Tiedong Sun; Shaoqin Liu

doi:10.1021/acsabm.5c00376

Multimodal Synergistic Antimicrobial Activity of the Copper-Doped and Oxygen-Defective In Situ Nanocoating on Medical Titanium

Leizi Chi
, Jinteng Qi
, Zhuo Ma^*
, Zeshuai Zhang
, Yunfeng Qiu^*
, Tiedong Sun^*
, Shaoqin Liu^*

^*Corresponding author for this work

Zhengzhou University
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University
School of Life Science and Technology, Harbin Institute of Technology
School of Medicine and Health, Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

To combat escalating antibiotic resistance in titanium implant-associated infections, oxygen-vacancy-rich polydopamine/TiCu nanocoating (PDA/p-TiCu-300 °C) was developed on medical-grade titanium, uniquely enabling synergistic photothermal (PTT), photodynamic (PDT), and sonodynamic (SDT) antimicrobial strategies. Unlike previous dual-modal approaches, this trimodal strategy, activated by near-infrared light and ultrasound, achieved exceptional broad-spectrum bactericidal efficacy against both Escherichia coli (99.19% killing) and Staphylococcus aureus (95.03% killing) via enhanced reactive oxygen species (ROS) generation and membrane disruption. The engineered oxygen vacancies within the PDA/p-TiCu-300 °C nanocoating significantly boosted ROS production, outperforming conventional photocatalytic materials. Crucially, the nanocoatings demonstrated excellent in vitro cytocompatibility. This PTT-PDT-SDT platform exhibits synergistic multimodal bactericidal activity, overcoming the limitations of existing strategies and representing a paradigm shift in implant surface modification with significant translational potential against severe infections.

Original language	English
Pages (from-to)	3560-3570
Number of pages	11
Journal	ACS Applied Bio Materials
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/acsabm.5c00376
State	Published - 21 Apr 2025
Externally published	Yes

Keywords

antibacterial nanocoating
medical titanium-based implants
membrane disruption
oxygen vacancy
synergistic antibacterial

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10.1021/acsabm.5c00376

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@article{c2bf187b01d846508bc06075ea9bc4bd,

title = "Multimodal Synergistic Antimicrobial Activity of the Copper-Doped and Oxygen-Defective In Situ Nanocoating on Medical Titanium",

abstract = "To combat escalating antibiotic resistance in titanium implant-associated infections, oxygen-vacancy-rich polydopamine/TiCu nanocoating (PDA/p-TiCu-300 °C) was developed on medical-grade titanium, uniquely enabling synergistic photothermal (PTT), photodynamic (PDT), and sonodynamic (SDT) antimicrobial strategies. Unlike previous dual-modal approaches, this trimodal strategy, activated by near-infrared light and ultrasound, achieved exceptional broad-spectrum bactericidal efficacy against both Escherichia coli (99.19\% killing) and Staphylococcus aureus (95.03\% killing) via enhanced reactive oxygen species (ROS) generation and membrane disruption. The engineered oxygen vacancies within the PDA/p-TiCu-300 °C nanocoating significantly boosted ROS production, outperforming conventional photocatalytic materials. Crucially, the nanocoatings demonstrated excellent in vitro cytocompatibility. This PTT-PDT-SDT platform exhibits synergistic multimodal bactericidal activity, overcoming the limitations of existing strategies and representing a paradigm shift in implant surface modification with significant translational potential against severe infections.",

keywords = "antibacterial nanocoating, medical titanium-based implants, membrane disruption, oxygen vacancy, synergistic antibacterial",

author = "Leizi Chi and Jinteng Qi and Zhuo Ma and Zeshuai Zhang and Yunfeng Qiu and Tiedong Sun and Shaoqin Liu",

note = "Publisher Copyright: {\textcopyright} 2025 American Chemical Society.",

year = "2025",

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doi = "10.1021/acsabm.5c00376",

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T1 - Multimodal Synergistic Antimicrobial Activity of the Copper-Doped and Oxygen-Defective In Situ Nanocoating on Medical Titanium

AU - Chi, Leizi

AU - Qi, Jinteng

AU - Ma, Zhuo

AU - Zhang, Zeshuai

AU - Qiu, Yunfeng

AU - Sun, Tiedong

AU - Liu, Shaoqin

PY - 2025/4/21

Y1 - 2025/4/21

N2 - To combat escalating antibiotic resistance in titanium implant-associated infections, oxygen-vacancy-rich polydopamine/TiCu nanocoating (PDA/p-TiCu-300 °C) was developed on medical-grade titanium, uniquely enabling synergistic photothermal (PTT), photodynamic (PDT), and sonodynamic (SDT) antimicrobial strategies. Unlike previous dual-modal approaches, this trimodal strategy, activated by near-infrared light and ultrasound, achieved exceptional broad-spectrum bactericidal efficacy against both Escherichia coli (99.19% killing) and Staphylococcus aureus (95.03% killing) via enhanced reactive oxygen species (ROS) generation and membrane disruption. The engineered oxygen vacancies within the PDA/p-TiCu-300 °C nanocoating significantly boosted ROS production, outperforming conventional photocatalytic materials. Crucially, the nanocoatings demonstrated excellent in vitro cytocompatibility. This PTT-PDT-SDT platform exhibits synergistic multimodal bactericidal activity, overcoming the limitations of existing strategies and representing a paradigm shift in implant surface modification with significant translational potential against severe infections.

AB - To combat escalating antibiotic resistance in titanium implant-associated infections, oxygen-vacancy-rich polydopamine/TiCu nanocoating (PDA/p-TiCu-300 °C) was developed on medical-grade titanium, uniquely enabling synergistic photothermal (PTT), photodynamic (PDT), and sonodynamic (SDT) antimicrobial strategies. Unlike previous dual-modal approaches, this trimodal strategy, activated by near-infrared light and ultrasound, achieved exceptional broad-spectrum bactericidal efficacy against both Escherichia coli (99.19% killing) and Staphylococcus aureus (95.03% killing) via enhanced reactive oxygen species (ROS) generation and membrane disruption. The engineered oxygen vacancies within the PDA/p-TiCu-300 °C nanocoating significantly boosted ROS production, outperforming conventional photocatalytic materials. Crucially, the nanocoatings demonstrated excellent in vitro cytocompatibility. This PTT-PDT-SDT platform exhibits synergistic multimodal bactericidal activity, overcoming the limitations of existing strategies and representing a paradigm shift in implant surface modification with significant translational potential against severe infections.

KW - antibacterial nanocoating

KW - medical titanium-based implants

KW - membrane disruption

KW - oxygen vacancy

KW - synergistic antibacterial

UR - https://www.scopus.com/pages/publications/105003207549

U2 - 10.1021/acsabm.5c00376

DO - 10.1021/acsabm.5c00376

M3 - 文章

C2 - 40208694

AN - SCOPUS:105003207549

SN - 2576-6422

VL - 8

SP - 3560

EP - 3570

JO - ACS Applied Bio Materials

JF - ACS Applied Bio Materials

IS - 4

ER -

Multimodal Synergistic Antimicrobial Activity of the Copper-Doped and Oxygen-Defective In Situ Nanocoating on Medical Titanium

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Keywords

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