Multilayer giant unilamellar vesicles as a model of artificial tissue for drug screen

Wenbo Zhang; Xuejing Wang; Xiaojun Han

doi:10.1016/j.cplett.2018.12.041

Multilayer giant unilamellar vesicles as a model of artificial tissue for drug screen

Wenbo Zhang
, Xuejing Wang
, Xiaojun Han^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering, Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The artificial tissue model always attracts scientists’ interest. Herein we proposed a simple yet novel strategy to fabricate artificial tissues on the porous polycarbonate substrate with the help of poly-l-lysine. The prepared artificial tissues formed a barrier between donor chamber and acceptor chamber. Using doxorubicin (Dox) and tetracycline as typical hydrophilic and hydrophobic drugs, the artificial tissues are found to be suitable for drug screen studies.

Original language	English
Pages (from-to)	34-37
Number of pages	4
Journal	Chemical Physics Letters
Volume	717
DOIs	https://doi.org/10.1016/j.cplett.2018.12.041
State	Published - 16 Feb 2019
Externally published	Yes

Keywords

Artificial tissue
Drug screen
Electroformation
GUVs
PLL

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10.1016/j.cplett.2018.12.041

Cite this

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title = "Multilayer giant unilamellar vesicles as a model of artificial tissue for drug screen",

abstract = "The artificial tissue model always attracts scientists{\textquoteright} interest. Herein we proposed a simple yet novel strategy to fabricate artificial tissues on the porous polycarbonate substrate with the help of poly-l-lysine. The prepared artificial tissues formed a barrier between donor chamber and acceptor chamber. Using doxorubicin (Dox) and tetracycline as typical hydrophilic and hydrophobic drugs, the artificial tissues are found to be suitable for drug screen studies.",

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author = "Wenbo Zhang and Xuejing Wang and Xiaojun Han",

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AU - Zhang, Wenbo

AU - Wang, Xuejing

AU - Han, Xiaojun

PY - 2019/2/16

Y1 - 2019/2/16

N2 - The artificial tissue model always attracts scientists’ interest. Herein we proposed a simple yet novel strategy to fabricate artificial tissues on the porous polycarbonate substrate with the help of poly-l-lysine. The prepared artificial tissues formed a barrier between donor chamber and acceptor chamber. Using doxorubicin (Dox) and tetracycline as typical hydrophilic and hydrophobic drugs, the artificial tissues are found to be suitable for drug screen studies.

AB - The artificial tissue model always attracts scientists’ interest. Herein we proposed a simple yet novel strategy to fabricate artificial tissues on the porous polycarbonate substrate with the help of poly-l-lysine. The prepared artificial tissues formed a barrier between donor chamber and acceptor chamber. Using doxorubicin (Dox) and tetracycline as typical hydrophilic and hydrophobic drugs, the artificial tissues are found to be suitable for drug screen studies.

KW - Artificial tissue

KW - Drug screen

KW - Electroformation

KW - GUVs

KW - PLL

UR - https://www.scopus.com/pages/publications/85059821038

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DO - 10.1016/j.cplett.2018.12.041

M3 - 文章

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JO - Chemical Physics Letters

JF - Chemical Physics Letters

ER -

Multilayer giant unilamellar vesicles as a model of artificial tissue for drug screen

Abstract

Keywords

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