Monitoring of the central blood pressure waveform via a conformal ultrasonic device

Chonghe Wang; Xiaoshi Li; Hongjie Hu; Lin Zhang; Zhenlong Huang; Muyang Lin; Zhuorui Zhang; Zhenan Yin; Brady Huang; Hua Gong; Shubha Bhaskaran; Yue Gu; Mitsutoshi Makihata; Yuxuan Guo; Yusheng Lei; Yimu Chen; Chunfeng Wang; Yang Li; Tianjiao Zhang; Zeyu Chen; Albert P. Pisano; Liangfang Zhang; Qifa Zhou; Sheng Xu

doi:10.1038/s41551-018-0287-x

Monitoring of the central blood pressure waveform via a conformal ultrasonic device

Chonghe Wang
, Xiaoshi Li
, Hongjie Hu
, Lin Zhang
, Zhenlong Huang
, Muyang Lin
, Zhuorui Zhang
, Zhenan Yin
, Brady Huang
, Hua Gong
, Shubha Bhaskaran
, Yue Gu
, Mitsutoshi Makihata
, Yuxuan Guo
, Yusheng Lei
, Yimu Chen
, Chunfeng Wang
, Yang Li
, Tianjiao Zhang
, Zeyu Chen

Albert P. Pisano, Liangfang Zhang, Qifa Zhou, Sheng Xu^*

^*Corresponding author for this work

University of California at San Diego
Tianjin University
Zhengzhou University
University of Southern California

Research output: Contribution to journal › Article › peer-review

830 Scopus citations

Abstract

Continuous monitoring of the central blood pressure waveform from deeply embedded vessels such as the carotid artery and jugular vein has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments.

Original language	English
Pages (from-to)	687-695
Number of pages	9
Journal	Nature Biomedical Engineering
Volume	2
Issue number	9
DOIs	https://doi.org/10.1038/s41551-018-0287-x
State	Published - 1 Sep 2018
Externally published	Yes

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Wang, C., Li, X., Hu, H., Zhang, L., Huang, Z., Lin, M., Zhang, Z., Yin, Z., Huang, B., Gong, H., Bhaskaran, S., Gu, Y., Makihata, M., Guo, Y., Lei, Y., Chen, Y., Wang, C., Li, Y., Zhang, T., ... Xu, S. (2018). Monitoring of the central blood pressure waveform via a conformal ultrasonic device. Nature Biomedical Engineering, 2(9), 687-695. https://doi.org/10.1038/s41551-018-0287-x

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title = "Monitoring of the central blood pressure waveform via a conformal ultrasonic device",

abstract = "Continuous monitoring of the central blood pressure waveform from deeply embedded vessels such as the carotid artery and jugular vein has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60\%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments.",

author = "Chonghe Wang and Xiaoshi Li and Hongjie Hu and Lin Zhang and Zhenlong Huang and Muyang Lin and Zhuorui Zhang and Zhenan Yin and Brady Huang and Hua Gong and Shubha Bhaskaran and Yue Gu and Mitsutoshi Makihata and Yuxuan Guo and Yusheng Lei and Yimu Chen and Chunfeng Wang and Yang Li and Tianjiao Zhang and Zeyu Chen and Pisano, \{Albert P.\} and Liangfang Zhang and Qifa Zhou and Sheng Xu",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2018",

month = sep,

day = "1",

doi = "10.1038/s41551-018-0287-x",

language = "英语",

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Wang, C, Li, X, Hu, H, Zhang, L, Huang, Z, Lin, M, Zhang, Z, Yin, Z, Huang, B, Gong, H, Bhaskaran, S, Gu, Y, Makihata, M, Guo, Y, Lei, Y, Chen, Y, Wang, C, Li, Y, Zhang, T, Chen, Z, Pisano, AP, Zhang, L, Zhou, Q & Xu, S 2018, 'Monitoring of the central blood pressure waveform via a conformal ultrasonic device', Nature Biomedical Engineering, vol. 2, no. 9, pp. 687-695. https://doi.org/10.1038/s41551-018-0287-x

TY - JOUR

T1 - Monitoring of the central blood pressure waveform via a conformal ultrasonic device

AU - Wang, Chonghe

AU - Li, Xiaoshi

AU - Hu, Hongjie

AU - Zhang, Lin

AU - Huang, Zhenlong

AU - Lin, Muyang

AU - Zhang, Zhuorui

AU - Yin, Zhenan

AU - Huang, Brady

AU - Gong, Hua

AU - Bhaskaran, Shubha

AU - Gu, Yue

AU - Makihata, Mitsutoshi

AU - Guo, Yuxuan

AU - Lei, Yusheng

AU - Chen, Yimu

AU - Wang, Chunfeng

AU - Li, Yang

AU - Zhang, Tianjiao

AU - Chen, Zeyu

AU - Pisano, Albert P.

AU - Zhang, Liangfang

AU - Zhou, Qifa

AU - Xu, Sheng

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Continuous monitoring of the central blood pressure waveform from deeply embedded vessels such as the carotid artery and jugular vein has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments.

AB - Continuous monitoring of the central blood pressure waveform from deeply embedded vessels such as the carotid artery and jugular vein has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments.

UR - https://www.scopus.com/pages/publications/85053264474

U2 - 10.1038/s41551-018-0287-x

DO - 10.1038/s41551-018-0287-x

M3 - 文章

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SN - 2157-846X

VL - 2

SP - 687

EP - 695

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

IS - 9

ER -

Monitoring of the central blood pressure waveform via a conformal ultrasonic device

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