TY - JOUR
T1 - Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct
AU - Su, Lin
AU - Jin, Dongdong
AU - Wang, Yuqiong
AU - Wang, Qinglong
AU - Pan, Chengfeng
AU - Jiang, Shuai
AU - Yang, Haojin
AU - Yang, Zhengxin
AU - Wang, Xin
AU - Xia, Neng
AU - Chan, Kai Fung
AU - Chiu, Philip Wai Yan
AU - Sung, Joseph Jao Yiu
AU - Zhang, Li
N1 - Publisher Copyright:
© 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
PY - 2023/12
Y1 - 2023/12
N2 - The magnetic microrobots promise benefits in minimally invasive cell-based therapy. However, they generally suffer from an inevitable compromise between their magnetic responsiveness and biomedical functions. Herein, we report a modularized microrobot consisting of magnetic actuation (MA) and cell scaffold (CS) modules. The MA module with strong magnetism and pH-responsive deformability and the CS module with cell loading-release capabilities were fabricated by three-dimensional printing technique. Subsequently, assembly of modules was performed by designing a shaft-hole structure and customizing their relative dimensions, which enabled magnetic navigation in complex environments, while not deteriorating the cellular functionalities. On-demand disassembly at targeted lesion was then realized to facilitate CS module delivery and retrieval of the MA module. Furthermore, the feasibility of proposed system was validated in an in vivo rabbit bile duct. Therefore, this work presents a modular design–based strategy that enables uncompromised fabrication of multifunctional microrobots and stimulates their development for future cell-based therapy.
AB - The magnetic microrobots promise benefits in minimally invasive cell-based therapy. However, they generally suffer from an inevitable compromise between their magnetic responsiveness and biomedical functions. Herein, we report a modularized microrobot consisting of magnetic actuation (MA) and cell scaffold (CS) modules. The MA module with strong magnetism and pH-responsive deformability and the CS module with cell loading-release capabilities were fabricated by three-dimensional printing technique. Subsequently, assembly of modules was performed by designing a shaft-hole structure and customizing their relative dimensions, which enabled magnetic navigation in complex environments, while not deteriorating the cellular functionalities. On-demand disassembly at targeted lesion was then realized to facilitate CS module delivery and retrieval of the MA module. Furthermore, the feasibility of proposed system was validated in an in vivo rabbit bile duct. Therefore, this work presents a modular design–based strategy that enables uncompromised fabrication of multifunctional microrobots and stimulates their development for future cell-based therapy.
UR - https://www.scopus.com/pages/publications/85179902705
U2 - 10.1126/sciadv.adj0883
DO - 10.1126/sciadv.adj0883
M3 - 文章
C2 - 38100592
AN - SCOPUS:85179902705
SN - 2375-2548
VL - 9
JO - Science Advances
JF - Science Advances
IS - 50
M1 - eadj0883
ER -