TY - JOUR
T1 - Modular magnetic microrobot system for robust endoluminal navigation and high–radial force stent delivery in complex ductal anatomy
AU - Su, Lin
AU - Jin, Dongdong
AU - Xia, Neng
AU - Hao, Bo
AU - Jiang, Yihang
AU - Wang, Qinglong
AU - Yang, Haojin
AU - Wang, Xin
AU - Chan, Kai Fung
AU - Ma, Xing
AU - Chung, Jacqueline Pui Wah
AU - Chiu, Philip Wai Yan
AU - Zhang, Li
N1 - Publisher Copyright:
© 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
PY - 2025/10/22
Y1 - 2025/10/22
N2 - Endoluminal stent implantation is a common intervention strategy for treating obstructive lesions, but conventional delivery systems struggle to reach deep, tortuous ducts. To overcome this limitation, we present a magnetically controlled microrobot that integrates two functional modules: a magnetic actuation (MA) module for agile navigation and an ultrasound-responsive self-expanding stent module (ST module) for lesion-specific dilation. The system uses a dynamically tunable assembly mechanism governed by rotational direction enabling integrated locomotion (clockwise) and on-demand module separation (counterclockwise) at stenotic sites. The platform is compatible with intraoperative ultrasound, allowing real-time navigation and thermally triggered expansion in physiological environments. By synergizing programmable magnetic actuation, ultrasound-mediated expansion, and clinical workflow compatibility, the robot can navigate tortuous phantom ducts, achieving controlled stent deployment within 3 seconds and complete expansion within 30 seconds, permitting minimally invasive treatment of biliary strictures. This work advances microrobotic stent delivery by overcoming key barriers to clinical translation in endoluminal interventions.
AB - Endoluminal stent implantation is a common intervention strategy for treating obstructive lesions, but conventional delivery systems struggle to reach deep, tortuous ducts. To overcome this limitation, we present a magnetically controlled microrobot that integrates two functional modules: a magnetic actuation (MA) module for agile navigation and an ultrasound-responsive self-expanding stent module (ST module) for lesion-specific dilation. The system uses a dynamically tunable assembly mechanism governed by rotational direction enabling integrated locomotion (clockwise) and on-demand module separation (counterclockwise) at stenotic sites. The platform is compatible with intraoperative ultrasound, allowing real-time navigation and thermally triggered expansion in physiological environments. By synergizing programmable magnetic actuation, ultrasound-mediated expansion, and clinical workflow compatibility, the robot can navigate tortuous phantom ducts, achieving controlled stent deployment within 3 seconds and complete expansion within 30 seconds, permitting minimally invasive treatment of biliary strictures. This work advances microrobotic stent delivery by overcoming key barriers to clinical translation in endoluminal interventions.
UR - https://www.scopus.com/pages/publications/105019734733
U2 - 10.1126/sciadv.ady4339
DO - 10.1126/sciadv.ady4339
M3 - 文章
C2 - 41124263
AN - SCOPUS:105019734733
SN - 2375-2548
VL - 11
JO - Science Advances
JF - Science Advances
IS - 43
M1 - eady4339
ER -