TY - GEN
T1 - Modeling and simulation study on the treatment of sinus node ischemia by Chinese medicine Yiqi Tongyang
AU - Bai, Xiangyun
AU - Wang, Kuanquan
AU - Li, Qince
AU - Luo, Cunjin
AU - Zhang, Henggui
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/12/16
Y1 - 2020/12/16
N2 - Sinus node ischemia is mainly characterized by slow heart rate, which is caused by ischemia-induced changes in electrophysiological properties and ion homeostasis leading to prolonged pacing cycle length. According to the available data, research on the mechanism of sinus node ischemia has been reported, but the report on the drug treatment of the disease is scarce. In order to reveal the effect of Chinese medicine (Yiqi Tongyang) in sinus node ischemia, this paper uses rabbit sinus node center and periphery models to simulate the effects of medium and high doses of the Chinese medicine in ischemia at the sub-cellular, cellular and tissue levels, and to simulate the changes in cellular action potentials and tissue pacing functions to predict the drug efficacy. Simulation results showed that 1) the Chinese medicine can effectively shorten the pacing cycle, with negligible effect on the duration of cellular action potential and maximal diastolic potential, but can cause a decrease in the maximal depolarization velocity; 2) it accelerated the activation of ischemic sinus node-atrum tissue, so that the electrical excitatory activity of the tissue return to the normal state; 3) by comparing the simulation results of medium and high doses of the Chinese medicine, it was shown that the high dose group did not increase the heart rate significantly, while the medium dose group had a significant effect on the regulation of heart rate, indicating that the Chinese medicine (Yiqi Tongyang) can effectively treat sinus node ischemic disease.
AB - Sinus node ischemia is mainly characterized by slow heart rate, which is caused by ischemia-induced changes in electrophysiological properties and ion homeostasis leading to prolonged pacing cycle length. According to the available data, research on the mechanism of sinus node ischemia has been reported, but the report on the drug treatment of the disease is scarce. In order to reveal the effect of Chinese medicine (Yiqi Tongyang) in sinus node ischemia, this paper uses rabbit sinus node center and periphery models to simulate the effects of medium and high doses of the Chinese medicine in ischemia at the sub-cellular, cellular and tissue levels, and to simulate the changes in cellular action potentials and tissue pacing functions to predict the drug efficacy. Simulation results showed that 1) the Chinese medicine can effectively shorten the pacing cycle, with negligible effect on the duration of cellular action potential and maximal diastolic potential, but can cause a decrease in the maximal depolarization velocity; 2) it accelerated the activation of ischemic sinus node-atrum tissue, so that the electrical excitatory activity of the tissue return to the normal state; 3) by comparing the simulation results of medium and high doses of the Chinese medicine, it was shown that the high dose group did not increase the heart rate significantly, while the medium dose group had a significant effect on the regulation of heart rate, indicating that the Chinese medicine (Yiqi Tongyang) can effectively treat sinus node ischemic disease.
KW - Chinese medicine Yi qi Tongyang
KW - computational cardiology
KW - electrophysiological modeling and simulation
KW - sinus node ischemia
UR - https://www.scopus.com/pages/publications/85100355907
U2 - 10.1109/BIBM49941.2020.9313576
DO - 10.1109/BIBM49941.2020.9313576
M3 - 会议稿件
AN - SCOPUS:85100355907
T3 - Proceedings - 2020 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2020
SP - 1416
EP - 1423
BT - Proceedings - 2020 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2020
A2 - Park, Taesung
A2 - Cho, Young-Rae
A2 - Hu, Xiaohua Tony
A2 - Yoo, Illhoi
A2 - Woo, Hyun Goo
A2 - Wang, Jianxin
A2 - Facelli, Julio
A2 - Nam, Seungyoon
A2 - Kang, Mingon
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2020
Y2 - 16 December 2020 through 19 December 2020
ER -