Model approximation for switched genetic regulatory networks

The model approximation problem is studied in this paper for switched genetic regulatory networks (GRNs) with time-varying delays. We focus on constructing a reduced-order model to approximate the high-order GRNs considered under the switching signal subject to certain constraints, such that the approximation error system between the original and reduced-order systems is exponentially stable with a disturbance attenuation performance. The stability conditions and the disturbance attenuation performance are established by utilizing two integral inequality bounding techniques and the average dwell-time method for the approximation error system. Then, the solvability conditions for the reduced-order models for the GRNs are also established using the projection method. Furthermore, the model approximation problem can be transferred into a sequential minimization problem that is subject to linear matrix inequality constraints by using the cone complementarity algorithm. Finally, several examples are provided to illustrate the effectiveness and the advantages of the proposed methods.