MiR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

Liu Qi; He Hongjuan; Gu Ning; Han Zhengbin; Xing Yanjiang; Zeng Tiebo; Huang Zhijun; Wu Qiong

doi:10.1016/j.febslet.2013.01.070

MiR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

Liu Qi
, He Hongjuan
, Gu Ning
, Han Zhengbin
, Xing Yanjiang
, Zeng Tiebo
, Huang Zhijun
, Wu Qiong^*

^*Corresponding author for this work

School of Life Science and Technology, Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.

Original language	English
Pages (from-to)	775-781
Number of pages	7
Journal	FEBS Letters
Volume	587
Issue number	6
DOIs	https://doi.org/10.1016/j.febslet.2013.01.070
State	Published - 18 Mar 2013
Externally published	Yes

Keywords

Dnmt3a
Embryonic development
Spatiotemporal expression
miR-370

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10.1016/j.febslet.2013.01.070

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title = "MiR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a",

abstract = "MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.",

keywords = "Dnmt3a, Embryonic development, Spatiotemporal expression, miR-370",

author = "Liu Qi and He Hongjuan and Gu Ning and Han Zhengbin and Xing Yanjiang and Zeng Tiebo and Huang Zhijun and Wu Qiong",

year = "2013",

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doi = "10.1016/j.febslet.2013.01.070",

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TY - JOUR

T1 - MiR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

AU - Qi, Liu

AU - Hongjuan, He

AU - Ning, Gu

AU - Zhengbin, Han

AU - Yanjiang, Xing

AU - Tiebo, Zeng

AU - Zhijun, Huang

AU - Qiong, Wu

PY - 2013/3/18

Y1 - 2013/3/18

N2 - MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.

AB - MicroRNAs (miRNAs) are small non-coding RNAs that participate in a large variety of biological processes. In this paper, the spatiotemporal expression pattern of miR-370 was characterized during mouse embryonic development, and was found to be stage- and tissue-specifically expressed. In addition, through luciferase reporter assays and western blot analyses, DNA methyltransferase 3A (Dnmt3a) was identified as a directly regulated target of miR-370. Altogether, our results indicate that miR-370 may play important roles in the morphogenesis of diverse organs, especially brain and adrenal glands, by mediating Dnmt3a expression during mouse development.

KW - Dnmt3a

KW - Embryonic development

KW - Spatiotemporal expression

KW - miR-370

UR - https://www.scopus.com/pages/publications/84875208862

U2 - 10.1016/j.febslet.2013.01.070

DO - 10.1016/j.febslet.2013.01.070

M3 - 文章

C2 - 23399934

AN - SCOPUS:84875208862

SN - 0014-5793

VL - 587

SP - 775

EP - 781

JO - FEBS Letters

JF - FEBS Letters

IS - 6

ER -

MiR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

Abstract

Keywords

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