Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy

Xiaomin Gao; Mingru Zhang; Danlan Fang; Yuan Yu; Shaolong Qi; Xinyang Yu; Meiqi Cheng; Shoujun Zhu; Fei Kang; Kuikun Yang; Guocan Yu

doi:10.1039/d5cc01204j

Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy

Xiaomin Gao
, Mingru Zhang
, Danlan Fang
, Yuan Yu^*
, Shaolong Qi
, Xinyang Yu
, Meiqi Cheng
, Shoujun Zhu
, Fei Kang^*
, Kuikun Yang^*
, Guocan Yu^*

^*Corresponding author for this work

School of Life Science and Technology, Harbin Institute of Technology
Tsinghua University
The Fourth Military Medical University
Jilin University
Zhejiang Sci-Tech University

Research output: Contribution to journal › Article › peer-review

Abstract

Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of ⁹⁰Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.

Original language	English
Pages (from-to)	7313-7316
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	40
DOIs	https://doi.org/10.1039/d5cc01204j
State	Published - 10 Apr 2025
Externally published	Yes

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10.1039/d5cc01204j

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title = "Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy",

abstract = "Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of 90Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.",

author = "Xiaomin Gao and Mingru Zhang and Danlan Fang and Yuan Yu and Shaolong Qi and Xinyang Yu and Meiqi Cheng and Shoujun Zhu and Fei Kang and Kuikun Yang and Guocan Yu",

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doi = "10.1039/d5cc01204j",

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T1 - Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy

AU - Gao, Xiaomin

AU - Zhang, Mingru

AU - Fang, Danlan

AU - Yu, Yuan

AU - Qi, Shaolong

AU - Yu, Xinyang

AU - Cheng, Meiqi

AU - Zhu, Shoujun

AU - Kang, Fei

AU - Yang, Kuikun

AU - Yu, Guocan

PY - 2025/4/10

Y1 - 2025/4/10

N2 - Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of 90Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.

AB - Conventional macroaggregated albumin (MAA) often fails to accurately simulate the biodistribution of 90Y microspheres in hepatic artery perfusion scintigraphy due to density mismatch. By mineralizing MAA, we developed lightly mineralized MAA (L-MAA) and highly mineralized MAA (H-MAA) with controlled densities, which enabled more accurate simulation of the biodistribution of resin and glass microspheres.

UR - https://www.scopus.com/pages/publications/105003869239

U2 - 10.1039/d5cc01204j

DO - 10.1039/d5cc01204j

M3 - 文章

C2 - 40264281

AN - SCOPUS:105003869239

SN - 1359-7345

VL - 61

SP - 7313

EP - 7316

JO - Chemical Communications

JF - Chemical Communications

IS - 40

ER -

Mineralization of macroaggregated albumin for accurate biodistribution evaluation of pre-radiotherapy

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