Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

Hongyu Yin; Chenglong Zhao; Hengzhi You; Kunhua Lin; Hegui Gong

doi:10.1039/c2cc33232a

Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

Hongyu Yin
, Chenglong Zhao
, Hengzhi You
, Kunhua Lin
, Hegui Gong^*

^*Corresponding author for this work

Shanghai University

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc₂O and MgCl₂.

Original language	English
Pages (from-to)	7034-7036
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	56
DOIs	https://doi.org/10.1039/c2cc33232a
State	Published - 18 Jun 2012
Externally published	Yes

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title = "Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides",

abstract = "Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc2O and MgCl2.",

author = "Hongyu Yin and Chenglong Zhao and Hengzhi You and Kunhua Lin and Hegui Gong",

year = "2012",

month = jun,

day = "18",

doi = "10.1039/c2cc33232a",

language = "英语",

volume = "48",

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journal = "Chemical Communications",

issn = "1359-7345",

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T1 - Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

AU - Yin, Hongyu

AU - Zhao, Chenglong

AU - You, Hengzhi

AU - Lin, Kunhua

AU - Gong, Hegui

PY - 2012/6/18

Y1 - 2012/6/18

N2 - Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc2O and MgCl2.

AB - Ni-catalyzed ketone formation through mild reductive coupling of a diverse set of unactivated alkyl bromides and iodides with particularly aryl acid anhydrides was successfully developed using zinc as the terminal reductant. These conditions also allow direct coupling of alkyl iodides with aryl acids in the presence of Boc2O and MgCl2.

UR - https://www.scopus.com/pages/publications/84862516959

U2 - 10.1039/c2cc33232a

DO - 10.1039/c2cc33232a

M3 - 文章

C2 - 22684052

AN - SCOPUS:84862516959

SN - 1359-7345

VL - 48

SP - 7034

EP - 7036

JO - Chemical Communications

JF - Chemical Communications

IS - 56

ER -

Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides

Abstract

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