Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water

Lei Shi; Yong Qiang Tu; Min Wang; Fu Min Zhang; Chun An Fan

doi:10.1021/ol049936t

Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water

Lei Shi
, Yong Qiang Tu^*
, Min Wang
, Fu Min Zhang
, Chun An Fan

^*Corresponding author for this work

Lanzhou University

Research output: Contribution to journal › Article › peer-review

328 Scopus citations

Abstract

(Equation presented) An efficient three-component coupling of aldehyde, alkyne, and amine to generate propargylamines has been effected under microwave irradiation in water using only Cul catalyst without the noble metal cocatalyst. This method has proved to be applicable to a wide range of substrates. In addition, the preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.

Original language	English
Pages (from-to)	1001-1003
Number of pages	3
Journal	Organic Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1021/ol049936t
State	Published - 18 Mar 2004
Externally published	Yes

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10.1021/ol049936t

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title = "Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water",

abstract = "(Equation presented) An efficient three-component coupling of aldehyde, alkyne, and amine to generate propargylamines has been effected under microwave irradiation in water using only Cul catalyst without the noble metal cocatalyst. This method has proved to be applicable to a wide range of substrates. In addition, the preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.",

author = "Lei Shi and Tu, \{Yong Qiang\} and Min Wang and Zhang, \{Fu Min\} and Fan, \{Chun An\}",

year = "2004",

month = mar,

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doi = "10.1021/ol049936t",

language = "英语",

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pages = "1001--1003",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "6",

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TY - JOUR

T1 - Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water

AU - Shi, Lei

AU - Tu, Yong Qiang

AU - Wang, Min

AU - Zhang, Fu Min

AU - Fan, Chun An

PY - 2004/3/18

Y1 - 2004/3/18

N2 - (Equation presented) An efficient three-component coupling of aldehyde, alkyne, and amine to generate propargylamines has been effected under microwave irradiation in water using only Cul catalyst without the noble metal cocatalyst. This method has proved to be applicable to a wide range of substrates. In addition, the preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.

AB - (Equation presented) An efficient three-component coupling of aldehyde, alkyne, and amine to generate propargylamines has been effected under microwave irradiation in water using only Cul catalyst without the noble metal cocatalyst. This method has proved to be applicable to a wide range of substrates. In addition, the preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.

UR - https://www.scopus.com/pages/publications/1642487346

U2 - 10.1021/ol049936t

DO - 10.1021/ol049936t

M3 - 文章

AN - SCOPUS:1642487346

SN - 1523-7060

VL - 6

SP - 1001

EP - 1003

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water

Abstract

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